Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?

The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate...

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Autores principales:	Ciro Manzo, Marcin Milchert, Maria Natale, Marek Brzosko
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2020
Materias:	polymyalgia rheumatica checkpoint inhibitory therapy checkpoint inhibitors inflammatory indices. Medicine R
Acceso en línea:	https://doaj.org/article/0765b9d4f6eb4a3abdcecf24f938d427
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spelling	oai:doaj.org-article:0765b9d4f6eb4a3abdcecf24f938d4272021-12-02T17:18:53ZPolymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?0034-62332084-983410.5114/reum.2020.96549https://doaj.org/article/0765b9d4f6eb4a3abdcecf24f938d4272020-06-01T00:00:00Zhttps://www.termedia.pl/Polymyalgia-rheumatica-with-normal-inflammatory-indices-at-the-time-of-diagnosis-can-we-just-move-a-step-forward-,18,41057,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate and C-reactive protein concentrations at the time of diagnosis. In this short communication we investigated the possibility that in some patients with PMR the main pathogenic mechanism is constituted by inhibition of some checkpoints, such as programmed death receptor-1, programmed death ligand 1, and “cytotoxic” lymphocyte antigen 4. In these patients, the pathogenetic mechanisms underlying PMR can act much more upstream than commonly suggested. Also, we addressed the question of whether these patients should be considered as affected by PMR-like syndromes or by PMR subset.Ciro ManzoMarcin MilchertMaria NataleMarek BrzoskoTermedia Publishing Housearticlepolymyalgia rheumatica checkpoint inhibitory therapy checkpoint inhibitors inflammatory indices.MedicineRENRheumatology, Vol 58, Iss 3, Pp 184-186 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymyalgia rheumatica checkpoint inhibitory therapy checkpoint inhibitors inflammatory indices. Medicine R
spellingShingle	polymyalgia rheumatica checkpoint inhibitory therapy checkpoint inhibitors inflammatory indices. Medicine R Ciro Manzo Marcin Milchert Maria Natale Marek Brzosko Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
description	The existence of polymyalgia rheumatica (PMR) with normal inflammatory indices at the time of diagnosis still represents a diagnostic conundrum. According to the literature, some patients with PMR following immune checkpoint inhibitory therapy had normal values of both erythrocyte sedimentation rate and C-reactive protein concentrations at the time of diagnosis. In this short communication we investigated the possibility that in some patients with PMR the main pathogenic mechanism is constituted by inhibition of some checkpoints, such as programmed death receptor-1, programmed death ligand 1, and “cytotoxic” lymphocyte antigen 4. In these patients, the pathogenetic mechanisms underlying PMR can act much more upstream than commonly suggested. Also, we addressed the question of whether these patients should be considered as affected by PMR-like syndromes or by PMR subset.
format	article
author	Ciro Manzo Marcin Milchert Maria Natale Marek Brzosko
author_facet	Ciro Manzo Marcin Milchert Maria Natale Marek Brzosko
author_sort	Ciro Manzo
title	Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_short	Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_full	Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_fullStr	Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_full_unstemmed	Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
title_sort	polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?
publisher	Termedia Publishing House
publishDate	2020
url	https://doaj.org/article/0765b9d4f6eb4a3abdcecf24f938d427
work_keys_str_mv	AT ciromanzo polymyalgiarheumaticawithnormalinflammatoryindicesatthetimeofdiagnosiscanwejustmoveastepforward AT marcinmilchert polymyalgiarheumaticawithnormalinflammatoryindicesatthetimeofdiagnosiscanwejustmoveastepforward AT marianatale polymyalgiarheumaticawithnormalinflammatoryindicesatthetimeofdiagnosiscanwejustmoveastepforward AT marekbrzosko polymyalgiarheumaticawithnormalinflammatoryindicesatthetimeofdiagnosiscanwejustmoveastepforward
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Polymyalgia rheumatica with normal inflammatory indices at the time of diagnosis: can we just move a step forward?

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