Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

Geoffroy Vellieux,1,2 Justine Frija-Masson,1,2 Anny Rouvel-Tallec,1,2 Xavier Drouot,3 Marie-Pia d’Ortho1,2 1Université de Paris, NeuroDiderot, Inserm, Paris, F-75019, France; 2Centre du sommeil, Service de Physiologie – Explorations Fonctionnelles, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-7501...

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Autores principales:	Vellieux G, Frija-Masson J, Rouvel-Tallec A, Drouot X, d'Ortho MP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	narcolepsy cataplexy excessive daytime sleepiness orexin hypocretin remission Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/07663a678da843c884a7dab218287f02
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spelling	oai:doaj.org-article:07663a678da843c884a7dab218287f022021-12-02T18:13:53ZNarcolepsy Type 1: A Remitting Disease? An Unusual Case Report1179-1608https://doaj.org/article/07663a678da843c884a7dab218287f022021-09-01T00:00:00Zhttps://www.dovepress.com/narcolepsy-type-1-a-remitting-disease-an-unusual-case-report-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Geoffroy Vellieux,1,2 Justine Frija-Masson,1,2 Anny Rouvel-Tallec,1,2 Xavier Drouot,3 Marie-Pia d’Ortho1,2 1Université de Paris, NeuroDiderot, Inserm, Paris, F-75019, France; 2Centre du sommeil, Service de Physiologie – Explorations Fonctionnelles, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France; 3Neurophysiologie Clinique et Explorations Fonctionnelles, CHU de Poitiers, Poitiers, FranceCorrespondence: Geoffroy VellieuxUniversité de Paris, NeuroDiderot, Inserm, Paris, F-75019, FranceTel +33 140258401Fax +33 140257181Email geoffroy.vellieux@aphp.frAbstract: We describe the case of a male patient who was diagnosed with narcolepsy type 1 on the basis of sleep and wake symptoms, and the results of investigations including video-polysomnography, multiple sleep latency test, human leukocyte antigen status and orexin level in cerebrospinal fluid. During the first years after disease onset, the patient did not show any significant improvement despite treatment with a variety of stimulant and anti-cataplectic drugs. However, spontaneous remission of disease occurred after 15 years.Keywords: narcolepsy, cataplexy, excessive daytime sleepiness, orexin, hypocretin, remissionVellieux GFrija-Masson JRouvel-Tallec ADrouot Xd'Ortho MPDove Medical Pressarticlenarcolepsycataplexyexcessive daytime sleepinessorexinhypocretinremissionPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1669-1673 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	narcolepsy cataplexy excessive daytime sleepiness orexin hypocretin remission Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	narcolepsy cataplexy excessive daytime sleepiness orexin hypocretin remission Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Vellieux G Frija-Masson J Rouvel-Tallec A Drouot X d'Ortho MP Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
description	Geoffroy Vellieux,1,2 Justine Frija-Masson,1,2 Anny Rouvel-Tallec,1,2 Xavier Drouot,3 Marie-Pia d’Ortho1,2 1Université de Paris, NeuroDiderot, Inserm, Paris, F-75019, France; 2Centre du sommeil, Service de Physiologie – Explorations Fonctionnelles, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France; 3Neurophysiologie Clinique et Explorations Fonctionnelles, CHU de Poitiers, Poitiers, FranceCorrespondence: Geoffroy VellieuxUniversité de Paris, NeuroDiderot, Inserm, Paris, F-75019, FranceTel +33 140258401Fax +33 140257181Email geoffroy.vellieux@aphp.frAbstract: We describe the case of a male patient who was diagnosed with narcolepsy type 1 on the basis of sleep and wake symptoms, and the results of investigations including video-polysomnography, multiple sleep latency test, human leukocyte antigen status and orexin level in cerebrospinal fluid. During the first years after disease onset, the patient did not show any significant improvement despite treatment with a variety of stimulant and anti-cataplectic drugs. However, spontaneous remission of disease occurred after 15 years.Keywords: narcolepsy, cataplexy, excessive daytime sleepiness, orexin, hypocretin, remission
format	article
author	Vellieux G Frija-Masson J Rouvel-Tallec A Drouot X d'Ortho MP
author_facet	Vellieux G Frija-Masson J Rouvel-Tallec A Drouot X d'Ortho MP
author_sort	Vellieux G
title	Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
title_short	Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
title_full	Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
title_fullStr	Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
title_full_unstemmed	Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report
title_sort	narcolepsy type 1: a remitting disease? an unusual case report
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/07663a678da843c884a7dab218287f02
work_keys_str_mv	AT vellieuxg narcolepsytype1aremittingdiseaseanunusualcasereport AT frijamassonj narcolepsytype1aremittingdiseaseanunusualcasereport AT rouveltalleca narcolepsytype1aremittingdiseaseanunusualcasereport AT drouotx narcolepsytype1aremittingdiseaseanunusualcasereport AT dorthomp narcolepsytype1aremittingdiseaseanunusualcasereport
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Narcolepsy Type 1: A Remitting Disease? An Unusual Case Report

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