A focused very high energy electron beam for fractionated stereotactic radiotherapy
Abstract An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (sever...
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Nature Portfolio
2021
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oai:doaj.org-article:0766d00ad35a433bad6268a2925d92932021-12-02T13:31:11ZA focused very high energy electron beam for fractionated stereotactic radiotherapy10.1038/s41598-021-85451-82045-2322https://doaj.org/article/0766d00ad35a433bad6268a2925d92932021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85451-8https://doaj.org/toc/2045-2322Abstract An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below $$1 \%$$ 1 % and a focal spot of $$2.3 \times 2.6\;{\text {mm}}^2$$ 2.3 × 2.6 mm 2 . The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom.Kristoffer SvendsenDiego GuénotJonas Björklund SvenssonKristoffer PeterssonAnders PerssonOlle LundhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Kristoffer Svendsen Diego Guénot Jonas Björklund Svensson Kristoffer Petersson Anders Persson Olle Lundh A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| description |
Abstract An electron beam of very high energy (50–250 MeV) can potentially produce a more favourable radiotherapy dose distribution compared to a state-of-the-art photon based radiotherapy technique. To produce an electron beam of sufficiently high energy to allow for a long penetration depth (several cm), very large accelerating structures are needed when using conventional radio-frequency technology, which may not be possible due to economical or spatial constraints. In this paper, we show transport and focusing of laser wakefield accelerated electron beams with a maximum energy of 160 MeV using electromagnetic quadrupole magnets in a point-to-point imaging configuration, yielding a spatial uncertainty of less than 0.1 mm, a total charge variation below $$1 \%$$ 1 % and a focal spot of $$2.3 \times 2.6\;{\text {mm}}^2$$ 2.3 × 2.6 mm 2 . The electron beam was focused to control the depth dose distribution and to improve the dose conformality inside a phantom of cast acrylic slabs and radiochromic film. The phantom was irradiated from 36 different angles to obtain a dose distribution mimicking a stereotactic radiotherapy treatment, with a peak fractional dose of 2.72 Gy and a total maximum dose of 65 Gy. This was achieved with realistic constraints, including 23 cm of propagation through air before any dose deposition in the phantom. |
| format |
article |
| author |
Kristoffer Svendsen Diego Guénot Jonas Björklund Svensson Kristoffer Petersson Anders Persson Olle Lundh |
| author_facet |
Kristoffer Svendsen Diego Guénot Jonas Björklund Svensson Kristoffer Petersson Anders Persson Olle Lundh |
| author_sort |
Kristoffer Svendsen |
| title |
A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| title_short |
A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| title_full |
A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| title_fullStr |
A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| title_full_unstemmed |
A focused very high energy electron beam for fractionated stereotactic radiotherapy |
| title_sort |
focused very high energy electron beam for fractionated stereotactic radiotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0766d00ad35a433bad6268a2925d9293 |
| work_keys_str_mv |
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