miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling

The majority of high grade serous ovarian cancers originate from fallopian tube secretory epithelial cells (FTSECs). Here the authors show that miR-181a drives oncogenic transformation in FTSECs through the cooperative inhibition of the tumor suppressor RB1 and of STING, resulting in genomic instabi...

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Autores principales:	Matthew Knarr, Rita A. Avelar, Sreeja C. Sekhar, Lily J. Kwiatkowski, Michele L. Dziubinski, Jessica McAnulty, Stephanie Skala, Stefanie Avril, Ronny Drapkin, Analisa DiFeo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0767a885d74b4bc6bb838ba3fa5b0523
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spelling	oai:doaj.org-article:0767a885d74b4bc6bb838ba3fa5b05232021-12-02T17:45:00ZmiR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling10.1038/s41467-020-17030-w2041-1723https://doaj.org/article/0767a885d74b4bc6bb838ba3fa5b05232020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17030-whttps://doaj.org/toc/2041-1723The majority of high grade serous ovarian cancers originate from fallopian tube secretory epithelial cells (FTSECs). Here the authors show that miR-181a drives oncogenic transformation in FTSECs through the cooperative inhibition of the tumor suppressor RB1 and of STING, resulting in genomic instability and suppression of intrinsic interferon signaling.Matthew KnarrRita A. AvelarSreeja C. SekharLily J. KwiatkowskiMichele L. DziubinskiJessica McAnultyStephanie SkalaStefanie AvrilRonny DrapkinAnalisa DiFeoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew Knarr Rita A. Avelar Sreeja C. Sekhar Lily J. Kwiatkowski Michele L. Dziubinski Jessica McAnulty Stephanie Skala Stefanie Avril Ronny Drapkin Analisa DiFeo miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
description	The majority of high grade serous ovarian cancers originate from fallopian tube secretory epithelial cells (FTSECs). Here the authors show that miR-181a drives oncogenic transformation in FTSECs through the cooperative inhibition of the tumor suppressor RB1 and of STING, resulting in genomic instability and suppression of intrinsic interferon signaling.
format	article
author	Matthew Knarr Rita A. Avelar Sreeja C. Sekhar Lily J. Kwiatkowski Michele L. Dziubinski Jessica McAnulty Stephanie Skala Stefanie Avril Ronny Drapkin Analisa DiFeo
author_facet	Matthew Knarr Rita A. Avelar Sreeja C. Sekhar Lily J. Kwiatkowski Michele L. Dziubinski Jessica McAnulty Stephanie Skala Stefanie Avril Ronny Drapkin Analisa DiFeo
author_sort	Matthew Knarr
title	miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
title_short	miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
title_full	miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
title_fullStr	miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
title_full_unstemmed	miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
title_sort	mir-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0767a885d74b4bc6bb838ba3fa5b0523
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miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling

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