Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease

Abstract The basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer’s disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from...

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Autores principales:	Ivanna M. Pavisic, Yoni Pertzov, Jennifer M. Nicholas, Antoinette O’Connor, Kirsty Lu, Keir X. X. Yong, Masud Husain, Nick C. Fox, Sebastian J. Crutch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0769aa9611594411a66c72f79667a41f
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spelling	oai:doaj.org-article:0769aa9611594411a66c72f79667a41f2021-12-02T18:27:47ZEye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease10.1038/s41598-021-88001-42045-2322https://doaj.org/article/0769aa9611594411a66c72f79667a41f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88001-4https://doaj.org/toc/2045-2322Abstract The basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer’s disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from a familial Alzheimer’s disease (FAD) cohort (9 symptomatic carriers, 17 presymptomatic carriers and 26 controls) completed the “Object-localisation” VSTM task while an eye-tracker recorded eye movements during the stimulus presentation. VSTM function and oculomotor performance were compared between groups and their association during encoding investigated. Compared to controls, symptomatic FAD carriers showed eye movement patterns suggestive of an ineffective encoding and presymptomatic FAD carriers within 6 years of their expected age at symptom onset, were more reliant on the stimuli fixation time to achieve accuracy in the localisation of the target. Consequently, for shorter fixation times on the stimuli, presymptomatic carriers were less accurate at localising the target than controls. By contrast, the only deficits detected on behavioural VSTM function was in symptomatic individuals. Our findings provide novel evidence that encoding processes may be vulnerable and weakened in presymptomatic FAD carriers, most prominently for spatial memory, suggesting a possible explanation for the subtle VSTM impairments observed in the preclinical stages of AD.Ivanna M. PavisicYoni PertzovJennifer M. NicholasAntoinette O’ConnorKirsty LuKeir X. X. YongMasud HusainNick C. FoxSebastian J. CrutchNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivanna M. Pavisic Yoni Pertzov Jennifer M. Nicholas Antoinette O’Connor Kirsty Lu Keir X. X. Yong Masud Husain Nick C. Fox Sebastian J. Crutch Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
description	Abstract The basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer’s disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from a familial Alzheimer’s disease (FAD) cohort (9 symptomatic carriers, 17 presymptomatic carriers and 26 controls) completed the “Object-localisation” VSTM task while an eye-tracker recorded eye movements during the stimulus presentation. VSTM function and oculomotor performance were compared between groups and their association during encoding investigated. Compared to controls, symptomatic FAD carriers showed eye movement patterns suggestive of an ineffective encoding and presymptomatic FAD carriers within 6 years of their expected age at symptom onset, were more reliant on the stimuli fixation time to achieve accuracy in the localisation of the target. Consequently, for shorter fixation times on the stimuli, presymptomatic carriers were less accurate at localising the target than controls. By contrast, the only deficits detected on behavioural VSTM function was in symptomatic individuals. Our findings provide novel evidence that encoding processes may be vulnerable and weakened in presymptomatic FAD carriers, most prominently for spatial memory, suggesting a possible explanation for the subtle VSTM impairments observed in the preclinical stages of AD.
format	article
author	Ivanna M. Pavisic Yoni Pertzov Jennifer M. Nicholas Antoinette O’Connor Kirsty Lu Keir X. X. Yong Masud Husain Nick C. Fox Sebastian J. Crutch
author_facet	Ivanna M. Pavisic Yoni Pertzov Jennifer M. Nicholas Antoinette O’Connor Kirsty Lu Keir X. X. Yong Masud Husain Nick C. Fox Sebastian J. Crutch
author_sort	Ivanna M. Pavisic
title	Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
title_short	Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
title_full	Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
title_fullStr	Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
title_full_unstemmed	Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
title_sort	eye-tracking indices of impaired encoding of visual short-term memory in familial alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0769aa9611594411a66c72f79667a41f
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Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease

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