Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.

<h4>Object</h4>This study aimed to combine plasma protein SerpinA5 with uterine artery doppler ultrasound and clinical risk factor during the first trimester for prediction of preeclampsia.<h4>Methods and materials</h4>This study was a nested cohort study and was divided into...

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Autores principales:	Yonggang Zhang, Yipeng Zhang, Limin Zhao, Junzhu Shi, Hongling Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/076acedcf12248d3bba8d91e57d9cdc3
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spelling	oai:doaj.org-article:076acedcf12248d3bba8d91e57d9cdc32021-12-02T20:19:12ZPlasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.1932-620310.1371/journal.pone.0258541https://doaj.org/article/076acedcf12248d3bba8d91e57d9cdc32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258541https://doaj.org/toc/1932-6203<h4>Object</h4>This study aimed to combine plasma protein SerpinA5 with uterine artery doppler ultrasound and clinical risk factor during the first trimester for prediction of preeclampsia.<h4>Methods and materials</h4>This study was a nested cohort study and was divided into the screening set and developing set. The plasma was collected during the first trimester (11+0-13+6 weeks), at the same time, UtA-PI was detected and recorded with four-dimensional color Doppler ultrasound. These pregnancies were followed up until after delivery. The plasma proteins were examined using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and enzyme linked immunosorbent assay (ELISA). Placental samples preserved after delivery were analysed by immunohistochemistry. Clinical risk factors were obtained from medical records or antenatal questionnaires. Upregulation or downregulation of SerpinA5 expression in TEV-1 cells was performed to investigate the role of SerpinA5 in trophoblasts invasion.<h4>Results</h4>We demonstrated that SerpinA5 levels were greater not only in preeclampsia placental tissue but also in plasma (both p<0.05), and we found that SerpinA5 may interfere with trophoblastic cell invasion by inhibiting MSP. SerpinA5 may be a potential predictor of preeclampsia. What is more, the sensitivity and specificity of predictive power were strengthened when plasma SerpinA5 was combined with UtA-PI and pre-pregnancy BMI & family history of PE for prediction of preeclampsia.<h4>Conclusion</h4>These findings showed that placenta-derived plasma SerpinA5 may be a novel biomarker for preeclampsia, which together with uterine artery Doppler ultrasound and clinical risk factor can more effectively predict preeclampsia.Yonggang ZhangYipeng ZhangLimin ZhaoJunzhu ShiHongling YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258541 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yonggang Zhang Yipeng Zhang Limin Zhao Junzhu Shi Hongling Yang Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
description	<h4>Object</h4>This study aimed to combine plasma protein SerpinA5 with uterine artery doppler ultrasound and clinical risk factor during the first trimester for prediction of preeclampsia.<h4>Methods and materials</h4>This study was a nested cohort study and was divided into the screening set and developing set. The plasma was collected during the first trimester (11+0-13+6 weeks), at the same time, UtA-PI was detected and recorded with four-dimensional color Doppler ultrasound. These pregnancies were followed up until after delivery. The plasma proteins were examined using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and enzyme linked immunosorbent assay (ELISA). Placental samples preserved after delivery were analysed by immunohistochemistry. Clinical risk factors were obtained from medical records or antenatal questionnaires. Upregulation or downregulation of SerpinA5 expression in TEV-1 cells was performed to investigate the role of SerpinA5 in trophoblasts invasion.<h4>Results</h4>We demonstrated that SerpinA5 levels were greater not only in preeclampsia placental tissue but also in plasma (both p<0.05), and we found that SerpinA5 may interfere with trophoblastic cell invasion by inhibiting MSP. SerpinA5 may be a potential predictor of preeclampsia. What is more, the sensitivity and specificity of predictive power were strengthened when plasma SerpinA5 was combined with UtA-PI and pre-pregnancy BMI & family history of PE for prediction of preeclampsia.<h4>Conclusion</h4>These findings showed that placenta-derived plasma SerpinA5 may be a novel biomarker for preeclampsia, which together with uterine artery Doppler ultrasound and clinical risk factor can more effectively predict preeclampsia.
format	article
author	Yonggang Zhang Yipeng Zhang Limin Zhao Junzhu Shi Hongling Yang
author_facet	Yonggang Zhang Yipeng Zhang Limin Zhao Junzhu Shi Hongling Yang
author_sort	Yonggang Zhang
title	Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
title_short	Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
title_full	Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
title_fullStr	Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
title_full_unstemmed	Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
title_sort	plasma serpina5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/076acedcf12248d3bba8d91e57d9cdc3
work_keys_str_mv	AT yonggangzhang plasmaserpina5inconjunctionwithuterinearterypulsatilityindexandclinicalriskfactorfortheearlypredictionofpreeclampsia AT yipengzhang plasmaserpina5inconjunctionwithuterinearterypulsatilityindexandclinicalriskfactorfortheearlypredictionofpreeclampsia AT liminzhao plasmaserpina5inconjunctionwithuterinearterypulsatilityindexandclinicalriskfactorfortheearlypredictionofpreeclampsia AT junzhushi plasmaserpina5inconjunctionwithuterinearterypulsatilityindexandclinicalriskfactorfortheearlypredictionofpreeclampsia AT honglingyang plasmaserpina5inconjunctionwithuterinearterypulsatilityindexandclinicalriskfactorfortheearlypredictionofpreeclampsia
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Plasma SerpinA5 in conjunction with uterine artery pulsatility index and clinical risk factor for the early prediction of preeclampsia.

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