NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline

Abstract Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a...

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Autores principales:	Constance Delaby, A. Julian, G. Page, S. Ragot, Sylvain Lehmann, M. Paccalin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/076f0bfa945b49fcac2db44a677b9cc7
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spelling	oai:doaj.org-article:076f0bfa945b49fcac2db44a677b9cc72021-12-02T16:50:17ZNFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline10.1038/s41598-021-89749-52045-2322https://doaj.org/article/076f0bfa945b49fcac2db44a677b9cc72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89749-5https://doaj.org/toc/2045-2322Abstract Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1β, IL-6, TNFα, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.Constance DelabyA. JulianG. PageS. RagotSylvain LehmannM. PaccalinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Constance Delaby A. Julian G. Page S. Ragot Sylvain Lehmann M. Paccalin NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
description	Abstract Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1β, IL-6, TNFα, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.
format	article
author	Constance Delaby A. Julian G. Page S. Ragot Sylvain Lehmann M. Paccalin
author_facet	Constance Delaby A. Julian G. Page S. Ragot Sylvain Lehmann M. Paccalin
author_sort	Constance Delaby
title	NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
title_short	NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
title_full	NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
title_fullStr	NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
title_full_unstemmed	NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
title_sort	nfl strongly correlates with tnf-r1 in the plasma of ad patients, but not with cognitive decline
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/076f0bfa945b49fcac2db44a677b9cc7
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NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline

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