Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection

Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection

Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.

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Detalles Bibliográficos
Autores principales: Ariadna Fernández-Calvet, Begoña Euba, Celia Gil-Campillo, Arancha Catalan-Moreno, Javier Moleres, Sara Martí, Alexandra Merlos, Jeroen D. Langereis, Francisco García-del Portillo, Lauren O. Bakaletz, Garth D. Ehrlich, Eric A. Porsch, Margarita Menéndez, Joshua C. Mell, Alejandro Toledo-Arana, Junkal Garmendia
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/07720d572d9e49e499e710710932f33f
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Descripción
Sumario:Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.

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