Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection

Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.

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Autores principales:	Ariadna Fernández-Calvet, Begoña Euba, Celia Gil-Campillo, Arancha Catalan-Moreno, Javier Moleres, Sara Martí, Alexandra Merlos, Jeroen D. Langereis, Francisco García-del Portillo, Lauren O. Bakaletz, Garth D. Ehrlich, Eric A. Porsch, Margarita Menéndez, Joshua C. Mell, Alejandro Toledo-Arana, Junkal Garmendia
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/07720d572d9e49e499e710710932f33f
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spelling	oai:doaj.org-article:07720d572d9e49e499e710710932f33f2021-11-03T21:15:03ZPhase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection2150-751110.1128/mBio.00789-21https://doaj.org/article/07720d572d9e49e499e710710932f33f2021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00789-21https://doaj.org/toc/2150-7511 Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.Ariadna Fernández-CalvetBegoña EubaCelia Gil-CampilloArancha Catalan-MorenoJavier MoleresSara MartíAlexandra MerlosJeroen D. LangereisFrancisco García-del PortilloLauren O. BakaletzGarth D. EhrlichEric A. PorschMargarita MenéndezJoshua C. MellAlejandro Toledo-AranaJunkal GarmendiaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Ariadna Fernández-Calvet Begoña Euba Celia Gil-Campillo Arancha Catalan-Moreno Javier Moleres Sara Martí Alexandra Merlos Jeroen D. Langereis Francisco García-del Portillo Lauren O. Bakaletz Garth D. Ehrlich Eric A. Porsch Margarita Menéndez Joshua C. Mell Alejandro Toledo-Arana Junkal Garmendia Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
description	Human-adapted bacterial pathogens have evolved specific mechanisms to colonize their host niche. Phase variation is a contingency strategy to allow adaptation to changing conditions, as phase-variable bacterial loci rapidly and reversibly switch their expression.
format	article
author	Ariadna Fernández-Calvet Begoña Euba Celia Gil-Campillo Arancha Catalan-Moreno Javier Moleres Sara Martí Alexandra Merlos Jeroen D. Langereis Francisco García-del Portillo Lauren O. Bakaletz Garth D. Ehrlich Eric A. Porsch Margarita Menéndez Joshua C. Mell Alejandro Toledo-Arana Junkal Garmendia
author_facet	Ariadna Fernández-Calvet Begoña Euba Celia Gil-Campillo Arancha Catalan-Moreno Javier Moleres Sara Martí Alexandra Merlos Jeroen D. Langereis Francisco García-del Portillo Lauren O. Bakaletz Garth D. Ehrlich Eric A. Porsch Margarita Menéndez Joshua C. Mell Alejandro Toledo-Arana Junkal Garmendia
author_sort	Ariadna Fernández-Calvet
title	Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
title_short	Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
title_full	Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
title_fullStr	Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
title_full_unstemmed	Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection
title_sort	phase variation in hmw1a controls a phenotypic switch in haemophilus influenzae associated with pathoadaptation during persistent infection
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/07720d572d9e49e499e710710932f33f
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Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection

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