Early-life chemical exposures and risk of metabolic syndrome

Nicole E De Long, Alison C Holloway Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada Abstract: The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challeng...

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Autores principales:	De Long NE, Holloway AC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Obesity Pesticides Polybrominated diphenyl ethers Heavy metals Acrylamide Endocrine Disrupting Chemicals Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0773482d96f247699078a52306e3cfee
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spelling	oai:doaj.org-article:0773482d96f247699078a52306e3cfee2021-12-02T03:03:28ZEarly-life chemical exposures and risk of metabolic syndrome1178-7007https://doaj.org/article/0773482d96f247699078a52306e3cfee2017-03-01T00:00:00Zhttps://www.dovepress.com/early-life-chemical-exposures-and-risk-of-metabolic-syndrome-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Nicole E De Long, Alison C Holloway Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada Abstract: The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity. Keywords: obesity, pesticides, polybrominated diphenyl ethers, heavy metals, acrylamide, endocrine-disrupting chemicalsDe Long NEHolloway ACDove Medical PressarticleObesityPesticidesPolybrominated diphenyl ethersHeavy metalsAcrylamideEndocrine Disrupting ChemicalsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 101-109 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity Pesticides Polybrominated diphenyl ethers Heavy metals Acrylamide Endocrine Disrupting Chemicals Specialties of internal medicine RC581-951
spellingShingle	Obesity Pesticides Polybrominated diphenyl ethers Heavy metals Acrylamide Endocrine Disrupting Chemicals Specialties of internal medicine RC581-951 De Long NE Holloway AC Early-life chemical exposures and risk of metabolic syndrome
description	Nicole E De Long, Alison C Holloway Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada Abstract: The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity. Keywords: obesity, pesticides, polybrominated diphenyl ethers, heavy metals, acrylamide, endocrine-disrupting chemicals
format	article
author	De Long NE Holloway AC
author_facet	De Long NE Holloway AC
author_sort	De Long NE
title	Early-life chemical exposures and risk of metabolic syndrome
title_short	Early-life chemical exposures and risk of metabolic syndrome
title_full	Early-life chemical exposures and risk of metabolic syndrome
title_fullStr	Early-life chemical exposures and risk of metabolic syndrome
title_full_unstemmed	Early-life chemical exposures and risk of metabolic syndrome
title_sort	early-life chemical exposures and risk of metabolic syndrome
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0773482d96f247699078a52306e3cfee
work_keys_str_mv	AT delongne earlylifechemicalexposuresandriskofmetabolicsyndrome AT hollowayac earlylifechemicalexposuresandriskofmetabolicsyndrome
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Early-life chemical exposures and risk of metabolic syndrome

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