Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity

Abstract The antineoplastic agent oxaliplatin induces a painful peripheral neuropathy characterized by an acute cold hypersensitivity. There is a lack of effective treatments to manage oxaliplatin-induced cold hypersensitivity which is due, in part, to a lack of understanding of the pathophysiology...

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Autores principales:	Kazuaki Nagasaka, Kazunori Yamanaka, Shinya Ogawa, Hiroyuki Takamatsu, Noriyuki Higo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07746a6861744710806ab6ddb2ecef60
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spelling	oai:doaj.org-article:07746a6861744710806ab6ddb2ecef602021-12-02T11:52:25ZBrain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity10.1038/s41598-017-04677-72045-2322https://doaj.org/article/07746a6861744710806ab6ddb2ecef602017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04677-7https://doaj.org/toc/2045-2322Abstract The antineoplastic agent oxaliplatin induces a painful peripheral neuropathy characterized by an acute cold hypersensitivity. There is a lack of effective treatments to manage oxaliplatin-induced cold hypersensitivity which is due, in part, to a lack of understanding of the pathophysiology of oxaliplatin-induced cold hypersensitivity. Thus, brain activity in oxaliplatin-treated macaques was examined using functional magnetic resonance imaging (fMRI). Oxaliplatin treatment reduced tail withdrawal latency to a cold (10 °C) stimulus, indicating cold hypersensitivity and increased activation in the secondary somatosensory cortex (SII) and the anterior insular cortex (Ins) was observed. By contrast, no activation was observed in these areas following cold stimulation in untreated macaques. Systemic treatment with an antinociceptive dose of the serotonergic-noradrenergic reuptake inhibitor duloxetine decreased SII and Ins activity. Pharmacological inactivation of SII and Ins activity by microinjection of the GABAA receptor agonist muscimol increased tail withdrawal latency. The current findings indicate that SII/Ins activity is a potential mediator of oxaliplatin-induced cold hypersensitivity.Kazuaki NagasakaKazunori YamanakaShinya OgawaHiroyuki TakamatsuNoriyuki HigoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuaki Nagasaka Kazunori Yamanaka Shinya Ogawa Hiroyuki Takamatsu Noriyuki Higo Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
description	Abstract The antineoplastic agent oxaliplatin induces a painful peripheral neuropathy characterized by an acute cold hypersensitivity. There is a lack of effective treatments to manage oxaliplatin-induced cold hypersensitivity which is due, in part, to a lack of understanding of the pathophysiology of oxaliplatin-induced cold hypersensitivity. Thus, brain activity in oxaliplatin-treated macaques was examined using functional magnetic resonance imaging (fMRI). Oxaliplatin treatment reduced tail withdrawal latency to a cold (10 °C) stimulus, indicating cold hypersensitivity and increased activation in the secondary somatosensory cortex (SII) and the anterior insular cortex (Ins) was observed. By contrast, no activation was observed in these areas following cold stimulation in untreated macaques. Systemic treatment with an antinociceptive dose of the serotonergic-noradrenergic reuptake inhibitor duloxetine decreased SII and Ins activity. Pharmacological inactivation of SII and Ins activity by microinjection of the GABAA receptor agonist muscimol increased tail withdrawal latency. The current findings indicate that SII/Ins activity is a potential mediator of oxaliplatin-induced cold hypersensitivity.
format	article
author	Kazuaki Nagasaka Kazunori Yamanaka Shinya Ogawa Hiroyuki Takamatsu Noriyuki Higo
author_facet	Kazuaki Nagasaka Kazunori Yamanaka Shinya Ogawa Hiroyuki Takamatsu Noriyuki Higo
author_sort	Kazuaki Nagasaka
title	Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
title_short	Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
title_full	Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
title_fullStr	Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
title_full_unstemmed	Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
title_sort	brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/07746a6861744710806ab6ddb2ecef60
work_keys_str_mv	AT kazuakinagasaka brainactivitychangesinamacaquemodelofoxaliplatininducedneuropathiccoldhypersensitivity AT kazunoriyamanaka brainactivitychangesinamacaquemodelofoxaliplatininducedneuropathiccoldhypersensitivity AT shinyaogawa brainactivitychangesinamacaquemodelofoxaliplatininducedneuropathiccoldhypersensitivity AT hiroyukitakamatsu brainactivitychangesinamacaquemodelofoxaliplatininducedneuropathiccoldhypersensitivity AT noriyukihigo brainactivitychangesinamacaquemodelofoxaliplatininducedneuropathiccoldhypersensitivity
_version_	1718395026913886208

Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity

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