Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

Previous work suggests that mitophagy in neurons is could be therapeutic in Alzheimer’s disease (AD). Here, the authors screen a library of drugs and identify UMI-77, a mitophagy inducer with beneficial effects in an AD mouse model, by binding MCL-1, which they identify as a mitophagy receptor.

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Autores principales:	Xufeng Cen, Yanying Chen, Xiaoyan Xu, Ronghai Wu, Fusheng He, Qingwei Zhao, Qiming Sun, Cong Yi, Jie Wu, Ayaz Najafov, Hongguang Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0778027b69704574ad5fc700df51b76a
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spelling	oai:doaj.org-article:0778027b69704574ad5fc700df51b76a2021-12-02T14:41:24ZPharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model10.1038/s41467-020-19547-62041-1723https://doaj.org/article/0778027b69704574ad5fc700df51b76a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19547-6https://doaj.org/toc/2041-1723Previous work suggests that mitophagy in neurons is could be therapeutic in Alzheimer’s disease (AD). Here, the authors screen a library of drugs and identify UMI-77, a mitophagy inducer with beneficial effects in an AD mouse model, by binding MCL-1, which they identify as a mitophagy receptor.Xufeng CenYanying ChenXiaoyan XuRonghai WuFusheng HeQingwei ZhaoQiming SunCong YiJie WuAyaz NajafovHongguang XiaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xufeng Cen Yanying Chen Xiaoyan Xu Ronghai Wu Fusheng He Qingwei Zhao Qiming Sun Cong Yi Jie Wu Ayaz Najafov Hongguang Xia Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
description	Previous work suggests that mitophagy in neurons is could be therapeutic in Alzheimer’s disease (AD). Here, the authors screen a library of drugs and identify UMI-77, a mitophagy inducer with beneficial effects in an AD mouse model, by binding MCL-1, which they identify as a mitophagy receptor.
format	article
author	Xufeng Cen Yanying Chen Xiaoyan Xu Ronghai Wu Fusheng He Qingwei Zhao Qiming Sun Cong Yi Jie Wu Ayaz Najafov Hongguang Xia
author_facet	Xufeng Cen Yanying Chen Xiaoyan Xu Ronghai Wu Fusheng He Qingwei Zhao Qiming Sun Cong Yi Jie Wu Ayaz Najafov Hongguang Xia
author_sort	Xufeng Cen
title	Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
title_short	Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
title_full	Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
title_fullStr	Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
title_full_unstemmed	Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model
title_sort	pharmacological targeting of mcl-1 promotes mitophagy and improves disease pathologies in an alzheimer’s disease mouse model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0778027b69704574ad5fc700df51b76a
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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

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