Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma.

Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma.

In a conceptual study of drug resistance we have used a preclinical model of malignant B-cell lines by combining drug induced growth inhibition and gene expression profiling. In the current report a melphalan resistance profile of 19 genes were weighted by microarray data from the MRC Myeloma IX tri...

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Autores principales: Martin Bøgsted, Anders E Bilgrau, Christopher P Wardell, Uta Bertsch, Alexander Schmitz, Julie S Bødker, Malene K Kjeldsen, Hartmut Goldschmidt, Gareth J Morgan, Karen Dybkaer, Hans E Johnsen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0778cf153500471da18c26b6bab43813
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