Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder

Shuhua Ran,1,* Zhiwei Zuo,2,* Chang Li,3 Xuntao Yin,4 Wei Qu,5 Qianying Tang,5 Yao Wang,1 Yanshu Shi,1 Haitao Li1 1Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, General Hospital of Western Theater Comm...

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Autores principales:	Ran S, Zuo Z, Li C, Yin X, Qu W, Tang Q, Wang Y, Shi Y, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	major depressive disorder asymmetry functional connectivity corpus callosum Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0779cf30a6b64b3eb9fe590dc7b55813
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spelling	oai:doaj.org-article:0779cf30a6b64b3eb9fe590dc7b558132021-12-02T13:03:10ZAtrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder1178-2021https://doaj.org/article/0779cf30a6b64b3eb9fe590dc7b558132020-06-01T00:00:00Zhttps://www.dovepress.com/atrophic-corpus-callosum-associated-with-altered-functional-asymmetry--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shuhua Ran,1,* Zhiwei Zuo,2,* Chang Li,3 Xuntao Yin,4 Wei Qu,5 Qianying Tang,5 Yao Wang,1 Yanshu Shi,1 Haitao Li1 1Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 3Department of Radiology, Daping Hospital, Army Medical University, Chongqing, People’s Republic of China; 4Department of Medical Imaging, Guizhou Provincial People’s Hospital, Guizhou, People’s Republic of China; 5Department of Psychology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haitao Li Email liihait@163.comPurpose: Impairments in intra- and inter-hemispheric information transfer circuits have been reported in patients with major depressive disorder (MDD). However, the specific anomalous connection (intra- and/or inter-hemispheric) and hemisphere (left and/or right) in which this connection plays a more dominant role in the pathogenic mechanism underlying MDD are still poorly understood.Patients and Methods: Structural magnetic resonance imaging and resting-state functional magnetic resonance imaging were performed in 33 patients with MDD and 33 healthy controls. The intra- and inter-hemispheric functional connectivity (FC) strength in the default mode network areas and volume of the callosal subregions were computed using independent samples t-tests. The partial correlations between the volumes and FCs were also computed.Results: The patients with MDD had smaller volumes in the genu of the corpus callosum than the controls. The intrahemispheric FCs of the bilateral posterior cingulate gyrus, left precuneus, left medial superior frontal gyrus, left medial orbitofrontal gyrus, left angular gyrus and left middle temporal gyrus, and interhemispheric FCs of the bilateral posterior cingulate gyrus in the patients with MDD were lower than those in the controls. Moreover, the intrahemispheric FCs of the precuneus and interhemispheric FCs of middle frontal gyrus, orbital middle frontal gyrus, and anterior cingulate gyrus in the patients with MDD showed right-lateralized asymmetry, which were opposite from the asymmetry patterns observed in the controls. The functional asymmetry of the anterior cingulate gyrus was correlated with the volume of the genu of the corpus callosum and disease duration.Conclusion: These findings provide robust evidence that intra- and inter-hemispheric disconnections are involved in MDD, and that functional disruptions in the left hemisphere may be more relevant to the pathophysiology of MDD. Furthermore, imbalanced interhemispheric exchanges may contribute to the anatomical deficits in the corpus callosum in patients with MDD.Keywords: major depressive disorder, asymmetry, functional connectivity, corpus callosumRan SZuo ZLi CYin XQu WTang QWang YShi YLi HDove Medical Pressarticlemajor depressive disorderasymmetryfunctional connectivitycorpus callosumNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1473-1482 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder asymmetry functional connectivity corpus callosum Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder asymmetry functional connectivity corpus callosum Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ran S Zuo Z Li C Yin X Qu W Tang Q Wang Y Shi Y Li H Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
description	Shuhua Ran,1,* Zhiwei Zuo,2,* Chang Li,3 Xuntao Yin,4 Wei Qu,5 Qianying Tang,5 Yao Wang,1 Yanshu Shi,1 Haitao Li1 1Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of Radiology, General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 3Department of Radiology, Daping Hospital, Army Medical University, Chongqing, People’s Republic of China; 4Department of Medical Imaging, Guizhou Provincial People’s Hospital, Guizhou, People’s Republic of China; 5Department of Psychology, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haitao Li Email liihait@163.comPurpose: Impairments in intra- and inter-hemispheric information transfer circuits have been reported in patients with major depressive disorder (MDD). However, the specific anomalous connection (intra- and/or inter-hemispheric) and hemisphere (left and/or right) in which this connection plays a more dominant role in the pathogenic mechanism underlying MDD are still poorly understood.Patients and Methods: Structural magnetic resonance imaging and resting-state functional magnetic resonance imaging were performed in 33 patients with MDD and 33 healthy controls. The intra- and inter-hemispheric functional connectivity (FC) strength in the default mode network areas and volume of the callosal subregions were computed using independent samples t-tests. The partial correlations between the volumes and FCs were also computed.Results: The patients with MDD had smaller volumes in the genu of the corpus callosum than the controls. The intrahemispheric FCs of the bilateral posterior cingulate gyrus, left precuneus, left medial superior frontal gyrus, left medial orbitofrontal gyrus, left angular gyrus and left middle temporal gyrus, and interhemispheric FCs of the bilateral posterior cingulate gyrus in the patients with MDD were lower than those in the controls. Moreover, the intrahemispheric FCs of the precuneus and interhemispheric FCs of middle frontal gyrus, orbital middle frontal gyrus, and anterior cingulate gyrus in the patients with MDD showed right-lateralized asymmetry, which were opposite from the asymmetry patterns observed in the controls. The functional asymmetry of the anterior cingulate gyrus was correlated with the volume of the genu of the corpus callosum and disease duration.Conclusion: These findings provide robust evidence that intra- and inter-hemispheric disconnections are involved in MDD, and that functional disruptions in the left hemisphere may be more relevant to the pathophysiology of MDD. Furthermore, imbalanced interhemispheric exchanges may contribute to the anatomical deficits in the corpus callosum in patients with MDD.Keywords: major depressive disorder, asymmetry, functional connectivity, corpus callosum
format	article
author	Ran S Zuo Z Li C Yin X Qu W Tang Q Wang Y Shi Y Li H
author_facet	Ran S Zuo Z Li C Yin X Qu W Tang Q Wang Y Shi Y Li H
author_sort	Ran S
title	Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
title_short	Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
title_full	Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
title_fullStr	Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
title_full_unstemmed	Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder
title_sort	atrophic corpus callosum associated with altered functional asymmetry in major depressive disorder
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0779cf30a6b64b3eb9fe590dc7b55813
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Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder

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