Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes

ABSTRACT Genes of prokaryotes and Archaea are often organized in cotranscribed groups, or operons. In contrast, eukaryotic genes are generally transcribed independently. Here we show that there is a substantial economic gain for the cell to cotranscribe genes encoding protein complexes because it sy...

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Autores principales:	Kim Sneppen, Steen Pedersen, Sandeep Krishna, Ian Dodd, Szabolcs Semsey
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2010
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0779fac2b67846499368adc398a8ff27
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spelling	oai:doaj.org-article:0779fac2b67846499368adc398a8ff272021-11-15T15:38:15ZEconomy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes10.1128/mBio.00177-102150-7511https://doaj.org/article/0779fac2b67846499368adc398a8ff272010-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00177-10https://doaj.org/toc/2150-7511ABSTRACT Genes of prokaryotes and Archaea are often organized in cotranscribed groups, or operons. In contrast, eukaryotic genes are generally transcribed independently. Here we show that there is a substantial economic gain for the cell to cotranscribe genes encoding protein complexes because it synchronizes the fluctuations, or noise, in the levels of the different components. This correlation substantially reduces the shortfall in production of the complex. This benefit is relatively large in small cells such as bacterial cells, in which there are few mRNAs and proteins per cell, and is diminished in larger cells such as eukaryotic cells.Kim SneppenSteen PedersenSandeep KrishnaIan DoddSzabolcs SemseyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 1, Iss 4 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Kim Sneppen Steen Pedersen Sandeep Krishna Ian Dodd Szabolcs Semsey Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
description	ABSTRACT Genes of prokaryotes and Archaea are often organized in cotranscribed groups, or operons. In contrast, eukaryotic genes are generally transcribed independently. Here we show that there is a substantial economic gain for the cell to cotranscribe genes encoding protein complexes because it synchronizes the fluctuations, or noise, in the levels of the different components. This correlation substantially reduces the shortfall in production of the complex. This benefit is relatively large in small cells such as bacterial cells, in which there are few mRNAs and proteins per cell, and is diminished in larger cells such as eukaryotic cells.
format	article
author	Kim Sneppen Steen Pedersen Sandeep Krishna Ian Dodd Szabolcs Semsey
author_facet	Kim Sneppen Steen Pedersen Sandeep Krishna Ian Dodd Szabolcs Semsey
author_sort	Kim Sneppen
title	Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
title_short	Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
title_full	Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
title_fullStr	Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
title_full_unstemmed	Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
title_sort	economy of operon formation: cotranscription minimizes shortfall in protein complexes
publisher	American Society for Microbiology
publishDate	2010
url	https://doaj.org/article/0779fac2b67846499368adc398a8ff27
work_keys_str_mv	AT kimsneppen economyofoperonformationcotranscriptionminimizesshortfallinproteincomplexes AT steenpedersen economyofoperonformationcotranscriptionminimizesshortfallinproteincomplexes AT sandeepkrishna economyofoperonformationcotranscriptionminimizesshortfallinproteincomplexes AT iandodd economyofoperonformationcotranscriptionminimizesshortfallinproteincomplexes AT szabolcssemsey economyofoperonformationcotranscriptionminimizesshortfallinproteincomplexes
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Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes

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