Structural and functional analysis of multi-interface domains.

A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the func...

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Autores principales:	Liang Zhao, Steven C H Hoi, Limsoon Wong, Tobias Hamp, Jinyan Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/077ad49ef40e4188bbe29c4184e85479
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spelling	oai:doaj.org-article:077ad49ef40e4188bbe29c4184e854792021-11-18T08:04:58ZStructural and functional analysis of multi-interface domains.1932-620310.1371/journal.pone.0050821https://doaj.org/article/077ad49ef40e4188bbe29c4184e854792012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272073/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the functions and interfaces as some subsets of the interfaces play the same function. This work applies graph theory and algorithms to discover fingerprints for the multiple interfaces of a domain and to establish associations between the interfaces and functions, based on a huge set of multi-interface proteins from PDB. We found that about 40% of proteins have the multi-interface property, however the involved multi-interface domains account for only a tiny fraction (1.8%) of the total number of domains. The interfaces of these domains are distinguishable in terms of their fingerprints, indicating the functional specificity of the multiple interfaces in a domain. Furthermore, we observed that both cooperative and distinctive structural patterns, which will be useful for protein engineering, exist in the multiple interfaces of a domain.Liang ZhaoSteven C H HoiLimsoon WongTobias HampJinyan LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e50821 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Zhao Steven C H Hoi Limsoon Wong Tobias Hamp Jinyan Li Structural and functional analysis of multi-interface domains.
description	A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the functions and interfaces as some subsets of the interfaces play the same function. This work applies graph theory and algorithms to discover fingerprints for the multiple interfaces of a domain and to establish associations between the interfaces and functions, based on a huge set of multi-interface proteins from PDB. We found that about 40% of proteins have the multi-interface property, however the involved multi-interface domains account for only a tiny fraction (1.8%) of the total number of domains. The interfaces of these domains are distinguishable in terms of their fingerprints, indicating the functional specificity of the multiple interfaces in a domain. Furthermore, we observed that both cooperative and distinctive structural patterns, which will be useful for protein engineering, exist in the multiple interfaces of a domain.
format	article
author	Liang Zhao Steven C H Hoi Limsoon Wong Tobias Hamp Jinyan Li
author_facet	Liang Zhao Steven C H Hoi Limsoon Wong Tobias Hamp Jinyan Li
author_sort	Liang Zhao
title	Structural and functional analysis of multi-interface domains.
title_short	Structural and functional analysis of multi-interface domains.
title_full	Structural and functional analysis of multi-interface domains.
title_fullStr	Structural and functional analysis of multi-interface domains.
title_full_unstemmed	Structural and functional analysis of multi-interface domains.
title_sort	structural and functional analysis of multi-interface domains.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/077ad49ef40e4188bbe29c4184e85479
work_keys_str_mv	AT liangzhao structuralandfunctionalanalysisofmultiinterfacedomains AT stevenchhoi structuralandfunctionalanalysisofmultiinterfacedomains AT limsoonwong structuralandfunctionalanalysisofmultiinterfacedomains AT tobiashamp structuralandfunctionalanalysisofmultiinterfacedomains AT jinyanli structuralandfunctionalanalysisofmultiinterfacedomains
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Structural and functional analysis of multi-interface domains.

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