THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS

The purpose of the study was to determine the level of proinflammatory cytokines: IL-12, IL-8 and IFNγ, neopterin and lipopolysaccharide-binding protein in the serum of patients with acute brucellosis before and after antibiotic therapy. The clinical data from 32 patients with laboratory-confirmed d...

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Autores principales:	N. I. Kovalevich, N. S. Sarkisyan, E. L. Rakitina, V. A. Galyas, I. V. Sannikova, O. V. Makhinya
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	brucellosis cytokines acute phase proteins of inflammation immune responses diagnostics immunopathogenesis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/078b48ccb8ab4ce192c9ddf73dd3caf4
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spelling	oai:doaj.org-article:078b48ccb8ab4ce192c9ddf73dd3caf42021-11-22T07:09:48ZTHE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS2220-76192313-739810.15789/2220-7619-2016-4-384-388https://doaj.org/article/078b48ccb8ab4ce192c9ddf73dd3caf42017-01-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/452https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The purpose of the study was to determine the level of proinflammatory cytokines: IL-12, IL-8 and IFNγ, neopterin and lipopolysaccharide-binding protein in the serum of patients with acute brucellosis before and after antibiotic therapy. The clinical data from 32 patients with laboratory-confirmed diagnosis — “acute brucellosis” admitted to the diagnosis, treatment and examination of occupational diseases brucellosis GBUZ SC “City Clinical Hospital No. 2”, the city of Stavropol were used in the study. The concentrations IL-12, IL-8, IFNγ cytokines and acute-phase proteins in serum was determined by ELISA. In the acute phase of brucellosis infection (before treatment) had high levels of pro-inflammatory cytokines IL-8 and IFNγ, but despite holding a course of antibiotic treatment in the serum of patients with preserved high levels of IL-8, indicative of active inflammation in the absence of clinical manifestations. IL-12 level, a key cytokine in the initiation of lymphocyte-dependent immune response was lower than in the control group. Evaluation of the cytokine status (IL-8, IL-12, IL-18) and proteins of acute inflammation phase (neopterin and lipopolysaccharide-binding protein) will provide valuable information for monitoring the effect of pharmacotherapy of acute brucellosis. Indicators of lipopolysaccharide-binding protein and neopterin in the serum of patients with brucellosis should be considered as a marker of inflammatory activity and as a predictor of outcome of acute brucellosis.N. I. KovalevichN. S. SarkisyanE. L. RakitinaV. A. GalyasI. V. SannikovaO. V. MakhinyaSankt-Peterburg : NIIÈM imeni Pasteraarticlebrucellosiscytokinesacute phase proteins of inflammationimmune responsesdiagnosticsimmunopathogenesisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 4, Pp 384-388 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	brucellosis cytokines acute phase proteins of inflammation immune responses diagnostics immunopathogenesis Infectious and parasitic diseases RC109-216
spellingShingle	brucellosis cytokines acute phase proteins of inflammation immune responses diagnostics immunopathogenesis Infectious and parasitic diseases RC109-216 N. I. Kovalevich N. S. Sarkisyan E. L. Rakitina V. A. Galyas I. V. Sannikova O. V. Makhinya THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
description	The purpose of the study was to determine the level of proinflammatory cytokines: IL-12, IL-8 and IFNγ, neopterin and lipopolysaccharide-binding protein in the serum of patients with acute brucellosis before and after antibiotic therapy. The clinical data from 32 patients with laboratory-confirmed diagnosis — “acute brucellosis” admitted to the diagnosis, treatment and examination of occupational diseases brucellosis GBUZ SC “City Clinical Hospital No. 2”, the city of Stavropol were used in the study. The concentrations IL-12, IL-8, IFNγ cytokines and acute-phase proteins in serum was determined by ELISA. In the acute phase of brucellosis infection (before treatment) had high levels of pro-inflammatory cytokines IL-8 and IFNγ, but despite holding a course of antibiotic treatment in the serum of patients with preserved high levels of IL-8, indicative of active inflammation in the absence of clinical manifestations. IL-12 level, a key cytokine in the initiation of lymphocyte-dependent immune response was lower than in the control group. Evaluation of the cytokine status (IL-8, IL-12, IL-18) and proteins of acute inflammation phase (neopterin and lipopolysaccharide-binding protein) will provide valuable information for monitoring the effect of pharmacotherapy of acute brucellosis. Indicators of lipopolysaccharide-binding protein and neopterin in the serum of patients with brucellosis should be considered as a marker of inflammatory activity and as a predictor of outcome of acute brucellosis.
format	article
author	N. I. Kovalevich N. S. Sarkisyan E. L. Rakitina V. A. Galyas I. V. Sannikova O. V. Makhinya
author_facet	N. I. Kovalevich N. S. Sarkisyan E. L. Rakitina V. A. Galyas I. V. Sannikova O. V. Makhinya
author_sort	N. I. Kovalevich
title	THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
title_short	THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
title_full	THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
title_fullStr	THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
title_full_unstemmed	THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS
title_sort	influence of pathogenetic therapy on the lever of cytokines in patients with acute brucellosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/078b48ccb8ab4ce192c9ddf73dd3caf4
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THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS

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