Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.

<h4>Introduction</h4>Good adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medicatio...

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Autores principales:	Eri Wakai, Kenji Ikemura, Chika Kato, Masahiro Okuda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/078d4a1a02ce4c6882b5729922511cd0
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spelling	oai:doaj.org-article:078d4a1a02ce4c6882b5729922511cd02021-12-02T20:10:48ZEffect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.1932-620310.1371/journal.pone.0252944https://doaj.org/article/078d4a1a02ce4c6882b5729922511cd02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252944https://doaj.org/toc/1932-6203<h4>Introduction</h4>Good adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medication adherence. However, the effect of medication regimen complexity on the therapeutic efficacy of medicines remains to be clarified. In the present study, we retrospectively investigated the effect of number of medications and medication regimen complexity on medication adherence and therapeutic efficacy in patients with hypertension.<h4>Methods</h4>According to the inclusion and exclusion criteria, 1,057 patients, who were on medications including antihypertensives on admission at the Mie University Hospital between July 2018 and December 2018, were enrolled in this study. Poor blood pressure management was defined if the systolic or diastolic blood pressure were ≥140 mmHg or ≥ 90 mmHg. Medication regimen complexity was quantified using the medication regimen complexity index (MRCI) score.<h4>Results</h4>Among 1,057 patients, 164 and 893 patients were categorized into poor and good adherence groups, respectively. The multivariate analyses revealed that age ≥ 71 years and oral MRCI score ≥ 19.5 but not number of oral medications were extracted as risk factors for poor medication adherence. Medication adherence and blood pressure management were poor in the group with oral MRCI score ≥ 19.5, regardless of the age. The rate of readmission was similar.<h4>Conclusion</h4>Our study is the first to demonstrate that medication regimen complexity rather than number of medications is closely related to medication adherence and blood pressure management. Hence, physicians and/or pharmacists should consider the complexity of medication regimens while modifying them.Eri WakaiKenji IkemuraChika KatoMasahiro OkudaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252944 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eri Wakai Kenji Ikemura Chika Kato Masahiro Okuda Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
description	<h4>Introduction</h4>Good adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medication adherence. However, the effect of medication regimen complexity on the therapeutic efficacy of medicines remains to be clarified. In the present study, we retrospectively investigated the effect of number of medications and medication regimen complexity on medication adherence and therapeutic efficacy in patients with hypertension.<h4>Methods</h4>According to the inclusion and exclusion criteria, 1,057 patients, who were on medications including antihypertensives on admission at the Mie University Hospital between July 2018 and December 2018, were enrolled in this study. Poor blood pressure management was defined if the systolic or diastolic blood pressure were ≥140 mmHg or ≥ 90 mmHg. Medication regimen complexity was quantified using the medication regimen complexity index (MRCI) score.<h4>Results</h4>Among 1,057 patients, 164 and 893 patients were categorized into poor and good adherence groups, respectively. The multivariate analyses revealed that age ≥ 71 years and oral MRCI score ≥ 19.5 but not number of oral medications were extracted as risk factors for poor medication adherence. Medication adherence and blood pressure management were poor in the group with oral MRCI score ≥ 19.5, regardless of the age. The rate of readmission was similar.<h4>Conclusion</h4>Our study is the first to demonstrate that medication regimen complexity rather than number of medications is closely related to medication adherence and blood pressure management. Hence, physicians and/or pharmacists should consider the complexity of medication regimens while modifying them.
format	article
author	Eri Wakai Kenji Ikemura Chika Kato Masahiro Okuda
author_facet	Eri Wakai Kenji Ikemura Chika Kato Masahiro Okuda
author_sort	Eri Wakai
title	Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
title_short	Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
title_full	Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
title_fullStr	Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
title_full_unstemmed	Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
title_sort	effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/078d4a1a02ce4c6882b5729922511cd0
work_keys_str_mv	AT eriwakai effectofnumberofmedicationsandcomplexityofregimensonmedicationadherenceandbloodpressuremanagementinhospitalizedpatientswithhypertension AT kenjiikemura effectofnumberofmedicationsandcomplexityofregimensonmedicationadherenceandbloodpressuremanagementinhospitalizedpatientswithhypertension AT chikakato effectofnumberofmedicationsandcomplexityofregimensonmedicationadherenceandbloodpressuremanagementinhospitalizedpatientswithhypertension AT masahirookuda effectofnumberofmedicationsandcomplexityofregimensonmedicationadherenceandbloodpressuremanagementinhospitalizedpatientswithhypertension
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Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.

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