Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging

Abstract A precise and thorough methodology is presented for the design and fabrication of bimodal phantoms to be used in medical microwave and ultrasound applications. Dielectric and acoustic properties of human soft tissues were simultaneously mimicked. The phantoms were fabricated using polyvinyl...

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Autores principales:	Enrique Villa, Natalia Arteaga-Marrero, Javier González-Fernández, Juan Ruiz-Alzola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/078df029a4d64e34abf4cb1a9b338a60
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spelling	oai:doaj.org-article:078df029a4d64e34abf4cb1a9b338a602021-12-02T15:09:48ZBimodal microwave and ultrasound phantoms for non-invasive clinical imaging10.1038/s41598-020-77368-52045-2322https://doaj.org/article/078df029a4d64e34abf4cb1a9b338a602020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77368-5https://doaj.org/toc/2045-2322Abstract A precise and thorough methodology is presented for the design and fabrication of bimodal phantoms to be used in medical microwave and ultrasound applications. Dielectric and acoustic properties of human soft tissues were simultaneously mimicked. The phantoms were fabricated using polyvinyl alcohol cryogel (PVA-C) as gelling agent at a 10% concentration. Sucrose was employed to control the dielectric properties in the microwave spectrum, whereas cellulose was used as acoustic scatterer for ultrasound. For the dielectric properties at microwaves, a mathematical model was extracted to calculate the complex permittivity of the desired mimicked tissues in the frequency range from 500 MHz to 20 GHz. This model, dependent on frequency and sucrose concentration, was in good agreement with the reference Cole–Cole model. Regarding the acoustic properties, the speed of sound and attenuation coefficient were employed for validation. In both cases, the experimental data were consistent with the corresponding theoretical values for soft tissues. The characterization of these PVA-C phantoms demonstrated a significant performance for simultaneous microwave and ultrasound operation. In conclusion, PVA-C has been validated as gelling agent for the fabrication of complex multimodal phantoms that mimic soft tissues providing a unique tool to be used in a range of clinical applications.Enrique VillaNatalia Arteaga-MarreroJavier González-FernándezJuan Ruiz-AlzolaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrique Villa Natalia Arteaga-Marrero Javier González-Fernández Juan Ruiz-Alzola Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
description	Abstract A precise and thorough methodology is presented for the design and fabrication of bimodal phantoms to be used in medical microwave and ultrasound applications. Dielectric and acoustic properties of human soft tissues were simultaneously mimicked. The phantoms were fabricated using polyvinyl alcohol cryogel (PVA-C) as gelling agent at a 10% concentration. Sucrose was employed to control the dielectric properties in the microwave spectrum, whereas cellulose was used as acoustic scatterer for ultrasound. For the dielectric properties at microwaves, a mathematical model was extracted to calculate the complex permittivity of the desired mimicked tissues in the frequency range from 500 MHz to 20 GHz. This model, dependent on frequency and sucrose concentration, was in good agreement with the reference Cole–Cole model. Regarding the acoustic properties, the speed of sound and attenuation coefficient were employed for validation. In both cases, the experimental data were consistent with the corresponding theoretical values for soft tissues. The characterization of these PVA-C phantoms demonstrated a significant performance for simultaneous microwave and ultrasound operation. In conclusion, PVA-C has been validated as gelling agent for the fabrication of complex multimodal phantoms that mimic soft tissues providing a unique tool to be used in a range of clinical applications.
format	article
author	Enrique Villa Natalia Arteaga-Marrero Javier González-Fernández Juan Ruiz-Alzola
author_facet	Enrique Villa Natalia Arteaga-Marrero Javier González-Fernández Juan Ruiz-Alzola
author_sort	Enrique Villa
title	Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
title_short	Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
title_full	Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
title_fullStr	Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
title_full_unstemmed	Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
title_sort	bimodal microwave and ultrasound phantoms for non-invasive clinical imaging
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/078df029a4d64e34abf4cb1a9b338a60
work_keys_str_mv	AT enriquevilla bimodalmicrowaveandultrasoundphantomsfornoninvasiveclinicalimaging AT nataliaarteagamarrero bimodalmicrowaveandultrasoundphantomsfornoninvasiveclinicalimaging AT javiergonzalezfernandez bimodalmicrowaveandultrasoundphantomsfornoninvasiveclinicalimaging AT juanruizalzola bimodalmicrowaveandultrasoundphantomsfornoninvasiveclinicalimaging
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Bimodal microwave and ultrasound phantoms for non-invasive clinical imaging

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