Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces

George E Aninwene II1, Chang Yao2, Thomas J Webster21Department of Biochemical Engineering, University of Maryland, Baltimore, MD; 2Division of Engineering, Brown University, Providence, RI, USAAbstract: Current orthopedic implants have functional lifetimes of only 10&ndash;15 years due to a...

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Autores principales:	George E Aninwene II, Chang Yao, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0792f1829d1e4d06a0e6101f9670e658
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spelling	oai:doaj.org-article:0792f1829d1e4d06a0e6101f9670e6582021-12-02T07:36:50ZEnhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces1176-91141178-2013https://doaj.org/article/0792f1829d1e4d06a0e6101f9670e6582008-06-01T00:00:00Zhttp://www.dovepress.com/enhanced-osteoblast-adhesion-to-drug-coated-anodized-nanotubular-titan-a1844https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013George E Aninwene II1, Chang Yao2, Thomas J Webster21Department of Biochemical Engineering, University of Maryland, Baltimore, MD; 2Division of Engineering, Brown University, Providence, RI, USAAbstract: Current orthopedic implants have functional lifetimes of only 10&ndash;15 years due to a variety of reasons including infection, extensive inflammation, and overall poor osseointegration (or a lack of prolonged bonding of the implant to juxtaposed bone). To improve properties of titanium for orthopedic applications, this study anodized and subsequently coated titanium with drugs known to reduce infection (penicillin/streptomycin) and inflammation (dexamethasone) using simple physical adsorption and the deposition of such drugs from simulated body fluid (SBF). Results showed improved drug elution from anodized nanotubular titanium when drugs were coated in the presence of SBF for up to 3 days. For the first time, results also showed that the simple physical adsorption of both penicillin/streptomycin and dexamethasone on anodized nanotubular titanium improved osteoblast numbers after 2 days of culture compared to uncoated unanodized titanium. In addition, results showed that depositing such drugs in SBF on anodized titanium was a more efficient method to promote osteoblast numbers compared to physical adsorption for up to 2 days of culture. In addition, osteoblast numbers increased on anodized titanium coated with drugs in SBF for up to 2 days of culture compared to unanodized titanium. In summary, compared to unanodized titanium, this preliminary study provided unexpected evidence of greater osteoblast numbers on anodized titanium coated with either penicillin/streptomycin or dexamethasone using simple physical adsorption or when coated with SBF; results which suggest the need for further research on anodized titanium orthopedic implants possessing drug-eluting nanotubes.Keywords: anodization, titanium, adhesion, simulated body fluid, nanotubes, osteoblasts George E Aninwene IIChang YaoThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 2, Pp 257-264 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 George E Aninwene II Chang Yao Thomas J Webster Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
description	George E Aninwene II1, Chang Yao2, Thomas J Webster21Department of Biochemical Engineering, University of Maryland, Baltimore, MD; 2Division of Engineering, Brown University, Providence, RI, USAAbstract: Current orthopedic implants have functional lifetimes of only 10&ndash;15 years due to a variety of reasons including infection, extensive inflammation, and overall poor osseointegration (or a lack of prolonged bonding of the implant to juxtaposed bone). To improve properties of titanium for orthopedic applications, this study anodized and subsequently coated titanium with drugs known to reduce infection (penicillin/streptomycin) and inflammation (dexamethasone) using simple physical adsorption and the deposition of such drugs from simulated body fluid (SBF). Results showed improved drug elution from anodized nanotubular titanium when drugs were coated in the presence of SBF for up to 3 days. For the first time, results also showed that the simple physical adsorption of both penicillin/streptomycin and dexamethasone on anodized nanotubular titanium improved osteoblast numbers after 2 days of culture compared to uncoated unanodized titanium. In addition, results showed that depositing such drugs in SBF on anodized titanium was a more efficient method to promote osteoblast numbers compared to physical adsorption for up to 2 days of culture. In addition, osteoblast numbers increased on anodized titanium coated with drugs in SBF for up to 2 days of culture compared to unanodized titanium. In summary, compared to unanodized titanium, this preliminary study provided unexpected evidence of greater osteoblast numbers on anodized titanium coated with either penicillin/streptomycin or dexamethasone using simple physical adsorption or when coated with SBF; results which suggest the need for further research on anodized titanium orthopedic implants possessing drug-eluting nanotubes.Keywords: anodization, titanium, adhesion, simulated body fluid, nanotubes, osteoblasts
format	article
author	George E Aninwene II Chang Yao Thomas J Webster
author_facet	George E Aninwene II Chang Yao Thomas J Webster
author_sort	George E Aninwene II
title	Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
title_short	Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
title_full	Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
title_fullStr	Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
title_full_unstemmed	Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
title_sort	enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/0792f1829d1e4d06a0e6101f9670e658
work_keys_str_mv	AT georgeeaninweneii enhancedosteoblastadhesiontodrugcoatedanodizednanotubulartitaniumsurfaces AT changyao enhancedosteoblastadhesiontodrugcoatedanodizednanotubulartitaniumsurfaces AT thomasjwebster enhancedosteoblastadhesiontodrugcoatedanodizednanotubulartitaniumsurfaces
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Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces

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