Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

<h4>Background</h4>Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice) display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce...

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Autores principales: Rabindra N Bhattacharjee, Birendranath Banerjee, Shizuo Akira, M Prakash Hande
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/0794f14187fb4e1eb68322c29a38ff9d
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