Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease

Abstract Polyunsaturated fatty acids (PUFA) are important for neuronal function and may contribute to the development of neurodegenerative diseases. Here, we investigated the correlation between dietary intake and plasma concentrations of PUFA and their associations with clinical severity in early-s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dallah Yoo, Yunsook Lim, Yiseul Son, Hyunkyung Rho, Chaewon Shin, Tae-Beom Ahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/079864cb30b94484b4b8edaa8fb50d25
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:079864cb30b94484b4b8edaa8fb50d25
record_format	dspace
spelling	oai:doaj.org-article:079864cb30b94484b4b8edaa8fb50d252021-12-02T17:22:57ZDietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease10.1038/s41598-021-92029-x2045-2322https://doaj.org/article/079864cb30b94484b4b8edaa8fb50d252021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92029-xhttps://doaj.org/toc/2045-2322Abstract Polyunsaturated fatty acids (PUFA) are important for neuronal function and may contribute to the development of neurodegenerative diseases. Here, we investigated the correlation between dietary intake and plasma concentrations of PUFA and their associations with clinical severity in early-stage Parkinson’s disease (PD). In a case–control study with 38 patients with PD and 33 controls, we assessed dietary intake using food frequency questionnaires and simultaneously measured the plasma levels of five PUFA. No differences were observed in dietary total energy and lipid intake, including PUFA, between patients with PD and controls. However, α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) plasma levels were lower in patients with PD. The association between dietary intake and plasma PUFA concentrations was not significant in patients with PD. ALA and LA plasma levels were inversely correlated with motor severity in patients with PD, while docosahexaenoic acid and AA plasma levels were positively correlated with non-motor symptoms after controlling for age and sex.Dallah YooYunsook LimYiseul SonHyunkyung RhoChaewon ShinTae-Beom AhnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dallah Yoo Yunsook Lim Yiseul Son Hyunkyung Rho Chaewon Shin Tae-Beom Ahn Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
description	Abstract Polyunsaturated fatty acids (PUFA) are important for neuronal function and may contribute to the development of neurodegenerative diseases. Here, we investigated the correlation between dietary intake and plasma concentrations of PUFA and their associations with clinical severity in early-stage Parkinson’s disease (PD). In a case–control study with 38 patients with PD and 33 controls, we assessed dietary intake using food frequency questionnaires and simultaneously measured the plasma levels of five PUFA. No differences were observed in dietary total energy and lipid intake, including PUFA, between patients with PD and controls. However, α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) plasma levels were lower in patients with PD. The association between dietary intake and plasma PUFA concentrations was not significant in patients with PD. ALA and LA plasma levels were inversely correlated with motor severity in patients with PD, while docosahexaenoic acid and AA plasma levels were positively correlated with non-motor symptoms after controlling for age and sex.
format	article
author	Dallah Yoo Yunsook Lim Yiseul Son Hyunkyung Rho Chaewon Shin Tae-Beom Ahn
author_facet	Dallah Yoo Yunsook Lim Yiseul Son Hyunkyung Rho Chaewon Shin Tae-Beom Ahn
author_sort	Dallah Yoo
title	Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
title_short	Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
title_full	Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
title_fullStr	Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
title_full_unstemmed	Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
title_sort	dietary intake and plasma levels of polyunsaturated fatty acids in early-stage parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/079864cb30b94484b4b8edaa8fb50d25
work_keys_str_mv	AT dallahyoo dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease AT yunsooklim dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease AT yiseulson dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease AT hyunkyungrho dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease AT chaewonshin dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease AT taebeomahn dietaryintakeandplasmalevelsofpolyunsaturatedfattyacidsinearlystageparkinsonsdisease
_version_	1718380948965294080

Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease

Ejemplares similares