Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study

Yoshiyuki Kita,1 Gábor Holló,2 Akiko Murai,1 Ritsuko Kita,1 Tsunehiro Saito,1 Akito Hirakata1 1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, Semmelweis University, Budapest, Hungary Purpose: To compare the relat...

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Autores principales:	Kita Y, Holló G, Murai A, Kita R, Saito T, Hirakata A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	circumpapillary ganglion cell complex circumpapillary total retina thickness circumpapillary retinal nerve fiber layer thickness glaucoma microperimetry sensitivity structure-function relationship Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/07999c9b154440b29b14b84295ca742d
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spelling	oai:doaj.org-article:07999c9b154440b29b14b84295ca742d2021-12-02T05:54:36ZCircumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study1177-5483https://doaj.org/article/07999c9b154440b29b14b84295ca742d2018-12-01T00:00:00Zhttps://www.dovepress.com/circumpapillary-structure-function-relationships-with-microperimetry-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yoshiyuki Kita,1 Gábor Holló,2 Akiko Murai,1 Ritsuko Kita,1 Tsunehiro Saito,1 Akito Hirakata1 1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, Semmelweis University, Budapest, Hungary Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes.Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector.Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector).Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma. Keywords: circumpapillary ganglion-cell complex, circumpapillary total retina thickness, circumpapillary retinal nerve-fiber-layer thickness, glaucoma, microperimetry sensitivity, structure-function relationshipKita YHolló GMurai AKita RSaito THirakata ADove Medical Pressarticlecircumpapillary ganglion cell complexcircumpapillary total retina thicknesscircumpapillary retinal nerve fiber layer thicknessglaucomamicroperimetry sensitivitystructure-function relationshipOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2535-2544 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	circumpapillary ganglion cell complex circumpapillary total retina thickness circumpapillary retinal nerve fiber layer thickness glaucoma microperimetry sensitivity structure-function relationship Ophthalmology RE1-994
spellingShingle	circumpapillary ganglion cell complex circumpapillary total retina thickness circumpapillary retinal nerve fiber layer thickness glaucoma microperimetry sensitivity structure-function relationship Ophthalmology RE1-994 Kita Y Holló G Murai A Kita R Saito T Hirakata A Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
description	Yoshiyuki Kita,1 Gábor Holló,2 Akiko Murai,1 Ritsuko Kita,1 Tsunehiro Saito,1 Akito Hirakata1 1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, Semmelweis University, Budapest, Hungary Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes.Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector.Results: Statistically significant correlations with circumpapillary MP-sensitivity values were found for cpRNFL in five sectors, cpTR in nine sectors, cpGCC in nine sectors, and cpOR in three sectors. The structure-function relationship was strong (r=0.4–0.69) in three sectors for cpRNFL, in six for cpTR, in four for cpGCC, and in one for cpOR. The relationship was very strong (r>0.7) in one sector for cpRNFL, cpTR, and cpGCC, and in no sectors for cpOR. The very strong relationships all occurred in sector 5 (inferotemporal sector).Conclusion: In our pilot study, the circumpapillary structure-function relationship was more extensive for cpTR thickness and cpGCC thickness than for cpRNFL thickness, which suggests that the former parameters may require greater attention in structure-function research into glaucoma. Keywords: circumpapillary ganglion-cell complex, circumpapillary total retina thickness, circumpapillary retinal nerve-fiber-layer thickness, glaucoma, microperimetry sensitivity, structure-function relationship
format	article
author	Kita Y Holló G Murai A Kita R Saito T Hirakata A
author_facet	Kita Y Holló G Murai A Kita R Saito T Hirakata A
author_sort	Kita Y
title	Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
title_short	Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
title_full	Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
title_fullStr	Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
title_full_unstemmed	Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
title_sort	circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/07999c9b154440b29b14b84295ca742d
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Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study

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