Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs

Abstract With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by...

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Autores principales:	Wei Qi, Longlong Tian, Wenzhen An, Qiang Wu, Jianli Liu, Can Jiang, Jun Yang, Bing Tang, Yafeng Zhang, Kangjun Xie, Xinling Wang, Zhan Li, Wangsuo Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/079b91fb74e44a1d8220f8cf33bc9e45
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spelling	oai:doaj.org-article:079b91fb74e44a1d8220f8cf33bc9e452021-12-02T15:18:54ZCuring the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs10.1038/s41598-017-02770-52045-2322https://doaj.org/article/079b91fb74e44a1d8220f8cf33bc9e452017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02770-5https://doaj.org/toc/2045-2322Abstract With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rarely studied. Therefore, isotope tracing and improved CT imaging techniques were used to investigate the biodistribution influence between oMWCNTs(oxidized multi-walled carbon nanotubes) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/or simvastatin (TD) in vivo. What’s more, biochemical indices in plasma and tissue histology were measured to further study therapeutic effects on the damages of oMWCNTs in mice. Isotope tracing and improved CT imaging results showed that low dosages of DOPC and TD didn’t affect the distribution of oMWCNTs in mice; conversely, the distribution and metabolism of DOPC and TD were influenced by oMWCNTs. Moreover, DOPC and/or TD improved the biocompatibility of oMWCNTs in erythrocyte suspension in vitro. Biochemical index and histopathological results indicated that DOPC and TD didn’t prevent injuries caused by oMWCNTs effectively. But TD showed a good therapeutic effect for damages. This study is the first to investigate prevention and treatment effects of drugs on damages caused by oMWCNTs and provides new insights and breakthroughs for management of nanoparticles on health hazards.Wei QiLonglong TianWenzhen AnQiang WuJianli LiuCan JiangJun YangBing TangYafeng ZhangKangjun XieXinling WangZhan LiWangsuo WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Qi Longlong Tian Wenzhen An Qiang Wu Jianli Liu Can Jiang Jun Yang Bing Tang Yafeng Zhang Kangjun Xie Xinling Wang Zhan Li Wangsuo Wu Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
description	Abstract With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rarely studied. Therefore, isotope tracing and improved CT imaging techniques were used to investigate the biodistribution influence between oMWCNTs(oxidized multi-walled carbon nanotubes) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/or simvastatin (TD) in vivo. What’s more, biochemical indices in plasma and tissue histology were measured to further study therapeutic effects on the damages of oMWCNTs in mice. Isotope tracing and improved CT imaging results showed that low dosages of DOPC and TD didn’t affect the distribution of oMWCNTs in mice; conversely, the distribution and metabolism of DOPC and TD were influenced by oMWCNTs. Moreover, DOPC and/or TD improved the biocompatibility of oMWCNTs in erythrocyte suspension in vitro. Biochemical index and histopathological results indicated that DOPC and TD didn’t prevent injuries caused by oMWCNTs effectively. But TD showed a good therapeutic effect for damages. This study is the first to investigate prevention and treatment effects of drugs on damages caused by oMWCNTs and provides new insights and breakthroughs for management of nanoparticles on health hazards.
format	article
author	Wei Qi Longlong Tian Wenzhen An Qiang Wu Jianli Liu Can Jiang Jun Yang Bing Tang Yafeng Zhang Kangjun Xie Xinling Wang Zhan Li Wangsuo Wu
author_facet	Wei Qi Longlong Tian Wenzhen An Qiang Wu Jianli Liu Can Jiang Jun Yang Bing Tang Yafeng Zhang Kangjun Xie Xinling Wang Zhan Li Wangsuo Wu
author_sort	Wei Qi
title	Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
title_short	Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
title_full	Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
title_fullStr	Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
title_full_unstemmed	Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs
title_sort	curing the toxicity of multi-walled carbon nanotubes through native small-molecule drugs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/079b91fb74e44a1d8220f8cf33bc9e45
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Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs

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