Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

Yalew Molla, Muluken Wubetu, Bekalu Dessie Pharmacy Department, Health Science College, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Yalew MollaPharmacy Department, Debre Markos University, PO Box, 269, Debre Markos, EthiopiaEmail yalew.molla2009@gmail.comBackground: Tuberculosis c...

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Autores principales:	Molla Y, Wubetu M, Dessie B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anti-tuberculosis drugs hepatotoxicity tuberculosis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/07a02042c4274e2e9131c57f1c89dce8
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spelling	oai:doaj.org-article:07a02042c4274e2e9131c57f1c89dce82021-12-02T14:08:53ZAnti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia1179-1535https://doaj.org/article/07a02042c4274e2e9131c57f1c89dce82021-01-01T00:00:00Zhttps://www.dovepress.com/anti-tuberculosis-drug-induced-hepatotoxicity-and-associated-factors-a-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Yalew Molla, Muluken Wubetu, Bekalu Dessie Pharmacy Department, Health Science College, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Yalew MollaPharmacy Department, Debre Markos University, PO Box, 269, Debre Markos, EthiopiaEmail yalew.molla2009@gmail.comBackground: Tuberculosis caused by susceptible mycobacterium tuberculosis strains is effectively treated by the first-line anti-tuberculosis drugs. However, most antibacterial drugs are known to induce hepatotoxicity which may limit their adherence and hence lead to the development of mycobacterial drug resistance.Objective: The aim of this study was to assess the incidence of anti-tuberculosis drug induced hepatotoxicity and associated factors among tuberculosis patients of Debre Markos, Mota, and Bichena Hospitals.Methods: The prospective cross sectional-study was conducted in three hospitals of East Gojjam zone by taking blood samples of new tuberculosis patients every 2 weeks for 2 months to measure the elevation of liver proteins indicating liver toxicity from the onset of starting therapy. A semi-structured questionnaire was also used to collect the socio-demographic data and factors of anti-tubeculosis drug induced liver toxicity. To identify factors associated with drug induced hepatotoxicity, binary logistic regression followed by multivariate analysis was applied at a statistically significant level of P< 0.05.Results: The incidence of hepatotoxicity among tuberculosis patients is 7.9%. Diagnosis of extrapulmonary tuberculosis, having comorbid disease, and old age are significantly associated (P< 0.05) with first-line antituberculosis drugs induced hepatotoxicity.Conclusion: The incidence of hepatotoxicity is relatively high among tuberculosis patients taking first-line anti-tuberculosis drugs. Therefore, the liver function of patients with old age, comorbid diseases, and extrapulmonary tuberculosis should be regularly monitored to reduce the severity of drug-induced hepatotoxicity.Keywords: anti-tuberculosis drugs, hepatotoxicity, tuberculosisMolla YWubetu MDessie BDove Medical Pressarticleanti-tuberculosis drugshepatotoxicitytuberculosisDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 13, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-tuberculosis drugs hepatotoxicity tuberculosis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	anti-tuberculosis drugs hepatotoxicity tuberculosis Diseases of the digestive system. Gastroenterology RC799-869 Molla Y Wubetu M Dessie B Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
description	Yalew Molla, Muluken Wubetu, Bekalu Dessie Pharmacy Department, Health Science College, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Yalew MollaPharmacy Department, Debre Markos University, PO Box, 269, Debre Markos, EthiopiaEmail yalew.molla2009@gmail.comBackground: Tuberculosis caused by susceptible mycobacterium tuberculosis strains is effectively treated by the first-line anti-tuberculosis drugs. However, most antibacterial drugs are known to induce hepatotoxicity which may limit their adherence and hence lead to the development of mycobacterial drug resistance.Objective: The aim of this study was to assess the incidence of anti-tuberculosis drug induced hepatotoxicity and associated factors among tuberculosis patients of Debre Markos, Mota, and Bichena Hospitals.Methods: The prospective cross sectional-study was conducted in three hospitals of East Gojjam zone by taking blood samples of new tuberculosis patients every 2 weeks for 2 months to measure the elevation of liver proteins indicating liver toxicity from the onset of starting therapy. A semi-structured questionnaire was also used to collect the socio-demographic data and factors of anti-tubeculosis drug induced liver toxicity. To identify factors associated with drug induced hepatotoxicity, binary logistic regression followed by multivariate analysis was applied at a statistically significant level of P< 0.05.Results: The incidence of hepatotoxicity among tuberculosis patients is 7.9%. Diagnosis of extrapulmonary tuberculosis, having comorbid disease, and old age are significantly associated (P< 0.05) with first-line antituberculosis drugs induced hepatotoxicity.Conclusion: The incidence of hepatotoxicity is relatively high among tuberculosis patients taking first-line anti-tuberculosis drugs. Therefore, the liver function of patients with old age, comorbid diseases, and extrapulmonary tuberculosis should be regularly monitored to reduce the severity of drug-induced hepatotoxicity.Keywords: anti-tuberculosis drugs, hepatotoxicity, tuberculosis
format	article
author	Molla Y Wubetu M Dessie B
author_facet	Molla Y Wubetu M Dessie B
author_sort	Molla Y
title	Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
title_short	Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
title_full	Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
title_fullStr	Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
title_full_unstemmed	Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia
title_sort	anti-tuberculosis drug induced hepatotoxicity and associated factors among tuberculosis patients at selected hospitals, ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/07a02042c4274e2e9131c57f1c89dce8
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_version_	1718391884887359488

Anti-Tuberculosis Drug Induced Hepatotoxicity and Associated Factors among Tuberculosis Patients at Selected Hospitals, Ethiopia

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