The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations

Abstract With the growing evidence on the variable human susceptibility against COVID-19, it is evident that some genetic loci modulate the severity of the infection. Recent studies have identified several loci associated with greater severity. More recently, a study has identified a 50 kb genomic s...

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Autores principales:	Prajjval Pratap Singh, Anshika Srivastava, Gazi Nurun Nahar Sultana, Nargis Khanam, Abhishek Pathak, Prashanth Suravajhala, Royana Singh, Pankaj Shrivastava, George van Driem, Kumarasamy Thangaraj, Gyaneshwer Chaubey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07a2760907714beb9858723e858cb0e8
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spelling	oai:doaj.org-article:07a2760907714beb9858723e858cb0e82021-12-02T17:30:46ZThe major genetic risk factor for severe COVID-19 does not show any association among South Asian populations10.1038/s41598-021-91711-42045-2322https://doaj.org/article/07a2760907714beb9858723e858cb0e82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91711-4https://doaj.org/toc/2045-2322Abstract With the growing evidence on the variable human susceptibility against COVID-19, it is evident that some genetic loci modulate the severity of the infection. Recent studies have identified several loci associated with greater severity. More recently, a study has identified a 50 kb genomic segment introgressed from Neanderthal adding a risk for COVID-19, and this genomic segment is present among 16% and 50% people of European and South Asian descent, respectively. Our studies on ACE2 identified a haplotype present among 20% and 60% of European and South Asian populations, respectively, which appears to be responsible for the low case fatality rate among South Asian populations. This result was also consistent with the real-time infection rate and case fatality rate among various states of India. We readdressed this issue using both of the contrasting datasets and compared them with the real-time infection rates and case fatality rate in India. We found that the polymorphism present in the 50 kb introgressed genomic segment (rs10490770) did not show any significant correlation with the infection and case fatality rate in India.Prajjval Pratap SinghAnshika SrivastavaGazi Nurun Nahar SultanaNargis KhanamAbhishek PathakPrashanth SuravajhalaRoyana SinghPankaj ShrivastavaGeorge van DriemKumarasamy ThangarajGyaneshwer ChaubeyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Prajjval Pratap Singh Anshika Srivastava Gazi Nurun Nahar Sultana Nargis Khanam Abhishek Pathak Prashanth Suravajhala Royana Singh Pankaj Shrivastava George van Driem Kumarasamy Thangaraj Gyaneshwer Chaubey The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
description	Abstract With the growing evidence on the variable human susceptibility against COVID-19, it is evident that some genetic loci modulate the severity of the infection. Recent studies have identified several loci associated with greater severity. More recently, a study has identified a 50 kb genomic segment introgressed from Neanderthal adding a risk for COVID-19, and this genomic segment is present among 16% and 50% people of European and South Asian descent, respectively. Our studies on ACE2 identified a haplotype present among 20% and 60% of European and South Asian populations, respectively, which appears to be responsible for the low case fatality rate among South Asian populations. This result was also consistent with the real-time infection rate and case fatality rate among various states of India. We readdressed this issue using both of the contrasting datasets and compared them with the real-time infection rates and case fatality rate in India. We found that the polymorphism present in the 50 kb introgressed genomic segment (rs10490770) did not show any significant correlation with the infection and case fatality rate in India.
format	article
author	Prajjval Pratap Singh Anshika Srivastava Gazi Nurun Nahar Sultana Nargis Khanam Abhishek Pathak Prashanth Suravajhala Royana Singh Pankaj Shrivastava George van Driem Kumarasamy Thangaraj Gyaneshwer Chaubey
author_facet	Prajjval Pratap Singh Anshika Srivastava Gazi Nurun Nahar Sultana Nargis Khanam Abhishek Pathak Prashanth Suravajhala Royana Singh Pankaj Shrivastava George van Driem Kumarasamy Thangaraj Gyaneshwer Chaubey
author_sort	Prajjval Pratap Singh
title	The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
title_short	The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
title_full	The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
title_fullStr	The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
title_full_unstemmed	The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations
title_sort	major genetic risk factor for severe covid-19 does not show any association among south asian populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07a2760907714beb9858723e858cb0e8
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The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations

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