Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

Xian Hui Lim,1 Monisha Esther Nongpiur,1– 3 Raymond P Najjar,2,3 Quan V Hoang,1– 4 Dan Milea,1– 3 Chee Wai Wong,1– 3 Rahat Husain,1,3 Hla Myint Htoon,2,3 Tin Aung,1– 3,5 Shamira Perera,1– 3 Tina Tzee Ling Wong1– 3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singap...

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Autores principales:	Lim XH, Nongpiur ME, Najjar RP, Hoang QV, Milea D, Wong CW, Husain R, Htoon HM, Aung T, Perera S, Wong TTL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	pattern electroretinogram visual field mean deviation optical coherence tomography retinal nerve fibre layer Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/07a5c2b406c24ad49099b535db58cb44
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spelling	oai:doaj.org-article:07a5c2b406c24ad49099b535db58cb442021-11-18T19:40:25ZSteady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia1177-5483https://doaj.org/article/07a5c2b406c24ad49099b535db58cb442021-11-01T00:00:00Zhttps://www.dovepress.com/steady-state-pattern-electroretinography-in-eyes-with-glaucoma-and-hig-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Xian Hui Lim,1 Monisha Esther Nongpiur,1– 3 Raymond P Najjar,2,3 Quan V Hoang,1– 4 Dan Milea,1– 3 Chee Wai Wong,1– 3 Rahat Husain,1,3 Hla Myint Htoon,2,3 Tin Aung,1– 3,5 Shamira Perera,1– 3 Tina Tzee Ling Wong1– 3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Duke-NUS Medical School, Singapore; 4Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, NY, USA; 5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeCorrespondence: Tina Tzee Ling WongSingapore National Eye Centre, 11 Third Hospital Avenue, 168751, SingaporeEmail tina.wong.t.l@singhealth.com.sgPurpose: To investigate features of the steady-state pattern electroretinogram (ssPERG) in subjects with glaucoma (G), high myopia (HM; spherical equivalent ≤-6D) and glaucoma with high myopia (GHM).Patients and Methods: Our study included 48 participants divided into 3 groups (G, HM, and GHM) who each underwent monocular ssPERG testing with Diopsys NOVA PERG protocols. The ConStim protocol detects distinct topographic patterns of dysfunction 16° and 24° around the central macula. MagD is the amplitude of the average signal and MagD/Mag ratio indicates the consistency of the response. ssPERG indices were compared between groups and correlated with functional (ie, visual field mean deviation (VFMD)) and structural (ie, average retinal nerve fibre layer (RNFL) thickness; Cirrus optical coherence tomography) features.Results: Participants had an average age of 59.4± 7.6 years. Mean Humphrey VFMD was − 14.22 ± 2.88dB, − 2.62 ± 1.18dB and − 12.80 ± 2.60dB for G, HM and GHM groups, respectively. Mean RNFL thickness was 63.0 ± 8.20μm, 69.5 ± 15.7μm and 60.6 ± 5.0μm for G, HM and GHM groups, respectively. For the 24° setting, no significant differences were noted for any of the parameters. For the 16° setting, MagD was lower in the GHM group compared to the HM group (0.29μV vs 0.52μV; p = 0.02). Significant differences were noted for the MagD/Mag ratio between HM and G groups (0.58 vs 0.40; p = 0.02) and between HM and GHM groups (0.58 vs 0.35; p = 0.002). There were positive correlations between both MagD 16° and MagD/Mag ratio 16° with VFMD (correlation coefficient [r]=0.37, p = 0.009; and r = 0.44, p = 0.002, respectively) and RNFL (r = 0.43, p = 0.002; and r = 0.48, p = 0.001, respectively).Conclusion: MagD/Mag ratio at 16° was significantly lower in glaucomatous eyes (with or without high myopia) compared to those with high myopia without glaucoma, suggesting that glaucoma has a distinct impact on MagD/Mag ratio at 16° irrespective of the presence of myopia.Keywords: pattern electroretinogram, visual field mean deviation, optical coherence tomography, retinal nerve fibre layerLim XHNongpiur MENajjar RPHoang QVMilea DWong CWHusain RHtoon HMAung TPerera SWong TTLDove Medical Pressarticlepattern electroretinogramvisual field mean deviationoptical coherence tomographyretinal nerve fibre layerOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4455-4465 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pattern electroretinogram visual field mean deviation optical coherence tomography retinal nerve fibre layer Ophthalmology RE1-994
spellingShingle	pattern electroretinogram visual field mean deviation optical coherence tomography retinal nerve fibre layer Ophthalmology RE1-994 Lim XH Nongpiur ME Najjar RP Hoang QV Milea D Wong CW Husain R Htoon HM Aung T Perera S Wong TTL Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
description	Xian Hui Lim,1 Monisha Esther Nongpiur,1– 3 Raymond P Najjar,2,3 Quan V Hoang,1– 4 Dan Milea,1– 3 Chee Wai Wong,1– 3 Rahat Husain,1,3 Hla Myint Htoon,2,3 Tin Aung,1– 3,5 Shamira Perera,1– 3 Tina Tzee Ling Wong1– 3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Duke-NUS Medical School, Singapore; 4Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, NY, USA; 5Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeCorrespondence: Tina Tzee Ling WongSingapore National Eye Centre, 11 Third Hospital Avenue, 168751, SingaporeEmail tina.wong.t.l@singhealth.com.sgPurpose: To investigate features of the steady-state pattern electroretinogram (ssPERG) in subjects with glaucoma (G), high myopia (HM; spherical equivalent ≤-6D) and glaucoma with high myopia (GHM).Patients and Methods: Our study included 48 participants divided into 3 groups (G, HM, and GHM) who each underwent monocular ssPERG testing with Diopsys NOVA PERG protocols. The ConStim protocol detects distinct topographic patterns of dysfunction 16° and 24° around the central macula. MagD is the amplitude of the average signal and MagD/Mag ratio indicates the consistency of the response. ssPERG indices were compared between groups and correlated with functional (ie, visual field mean deviation (VFMD)) and structural (ie, average retinal nerve fibre layer (RNFL) thickness; Cirrus optical coherence tomography) features.Results: Participants had an average age of 59.4± 7.6 years. Mean Humphrey VFMD was − 14.22 ± 2.88dB, − 2.62 ± 1.18dB and − 12.80 ± 2.60dB for G, HM and GHM groups, respectively. Mean RNFL thickness was 63.0 ± 8.20μm, 69.5 ± 15.7μm and 60.6 ± 5.0μm for G, HM and GHM groups, respectively. For the 24° setting, no significant differences were noted for any of the parameters. For the 16° setting, MagD was lower in the GHM group compared to the HM group (0.29μV vs 0.52μV; p = 0.02). Significant differences were noted for the MagD/Mag ratio between HM and G groups (0.58 vs 0.40; p = 0.02) and between HM and GHM groups (0.58 vs 0.35; p = 0.002). There were positive correlations between both MagD 16° and MagD/Mag ratio 16° with VFMD (correlation coefficient [r]=0.37, p = 0.009; and r = 0.44, p = 0.002, respectively) and RNFL (r = 0.43, p = 0.002; and r = 0.48, p = 0.001, respectively).Conclusion: MagD/Mag ratio at 16° was significantly lower in glaucomatous eyes (with or without high myopia) compared to those with high myopia without glaucoma, suggesting that glaucoma has a distinct impact on MagD/Mag ratio at 16° irrespective of the presence of myopia.Keywords: pattern electroretinogram, visual field mean deviation, optical coherence tomography, retinal nerve fibre layer
format	article
author	Lim XH Nongpiur ME Najjar RP Hoang QV Milea D Wong CW Husain R Htoon HM Aung T Perera S Wong TTL
author_facet	Lim XH Nongpiur ME Najjar RP Hoang QV Milea D Wong CW Husain R Htoon HM Aung T Perera S Wong TTL
author_sort	Lim XH
title	Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
title_short	Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
title_full	Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
title_fullStr	Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
title_full_unstemmed	Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia
title_sort	steady-state pattern electroretinography in eyes with glaucoma and high myopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/07a5c2b406c24ad49099b535db58cb44
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Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

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