Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.

<h4>Background</h4>Elevated baseline circulating alanine aminotransferase (ALT) level has been demonstrated to be associated with an increased risk of the metabolic syndrome (MetS), but the nature of the dose-response relationship is uncertain.<h4>Methods</h4>We performed a s...

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Autores principales:	Setor K Kunutsor, Dorothy Seddoh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07a5d0eec07147f5b7a175e14e9b94b0
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spelling	oai:doaj.org-article:07a5d0eec07147f5b7a175e14e9b94b02021-11-18T08:21:23ZAlanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.1932-620310.1371/journal.pone.0096068https://doaj.org/article/07a5d0eec07147f5b7a175e14e9b94b02014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24781277/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Elevated baseline circulating alanine aminotransferase (ALT) level has been demonstrated to be associated with an increased risk of the metabolic syndrome (MetS), but the nature of the dose-response relationship is uncertain.<h4>Methods</h4>We performed a systematic review and meta-analysis of published prospective cohort studies to characterize in detail the nature of the dose-response relationship between baseline ALT level and risk of incident MetS in the general population. Relevant studies were identified in a literature search of MEDLINE, EMBASE, and Web of Science up to December 2013. Prospective studies in which investigators reported relative risks (RRs) of MetS for 3 or more categories of ALT levels were eligible. A potential nonlinear relationship between ALT levels and MetS was examined using restricted cubic splines.<h4>Results</h4>Of the 489 studies reviewed, relevant data were available on 29,815 non-overlapping participants comprising 2,125 incident MetS events from five prospective cohort studies. There was evidence of a linear association (P for nonlinearity=0.38) between ALT level and risk of MetS, characterised by a graded increase in MetS risk at ALT levels 6-40 U/L. The risk of MetS increased by 14% for every 5 U/L increment in circulating ALT level (95% CI: 12-17%). Evidence was lacking of heterogeneity and publication bias among the contributing studies.<h4>Conclusions</h4>Baseline ALT level is associated with risk of the MetS in a linear dose-response manner. Studies are needed to determine whether the association represents a causal relationship.Setor K KunutsorDorothy SeddohPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e96068 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Setor K Kunutsor Dorothy Seddoh Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
description	<h4>Background</h4>Elevated baseline circulating alanine aminotransferase (ALT) level has been demonstrated to be associated with an increased risk of the metabolic syndrome (MetS), but the nature of the dose-response relationship is uncertain.<h4>Methods</h4>We performed a systematic review and meta-analysis of published prospective cohort studies to characterize in detail the nature of the dose-response relationship between baseline ALT level and risk of incident MetS in the general population. Relevant studies were identified in a literature search of MEDLINE, EMBASE, and Web of Science up to December 2013. Prospective studies in which investigators reported relative risks (RRs) of MetS for 3 or more categories of ALT levels were eligible. A potential nonlinear relationship between ALT levels and MetS was examined using restricted cubic splines.<h4>Results</h4>Of the 489 studies reviewed, relevant data were available on 29,815 non-overlapping participants comprising 2,125 incident MetS events from five prospective cohort studies. There was evidence of a linear association (P for nonlinearity=0.38) between ALT level and risk of MetS, characterised by a graded increase in MetS risk at ALT levels 6-40 U/L. The risk of MetS increased by 14% for every 5 U/L increment in circulating ALT level (95% CI: 12-17%). Evidence was lacking of heterogeneity and publication bias among the contributing studies.<h4>Conclusions</h4>Baseline ALT level is associated with risk of the MetS in a linear dose-response manner. Studies are needed to determine whether the association represents a causal relationship.
format	article
author	Setor K Kunutsor Dorothy Seddoh
author_facet	Setor K Kunutsor Dorothy Seddoh
author_sort	Setor K Kunutsor
title	Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
title_short	Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
title_full	Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
title_fullStr	Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
title_full_unstemmed	Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
title_sort	alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/07a5d0eec07147f5b7a175e14e9b94b0
work_keys_str_mv	AT setorkkunutsor alanineaminotransferaseandriskofthemetabolicsyndromealineardoseresponserelationship AT dorothyseddoh alanineaminotransferaseandriskofthemetabolicsyndromealineardoseresponserelationship
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Alanine aminotransferase and risk of the metabolic syndrome: a linear dose-response relationship.

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