Single cell derived mRNA signals across human kidney tumors

Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

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Autores principales:	Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Del Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost, Karin Straathof, Sam Behjati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
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spelling	oai:doaj.org-article:07a679f9a06e4d84ac2da9b571bfc2a42021-12-02T17:12:16ZSingle cell derived mRNA signals across human kidney tumors10.1038/s41467-021-23949-52041-1723https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23949-5https://doaj.org/toc/2041-1723Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.Matthew D. YoungThomas J. MitchellLars CustersThanasis MargaritisFrancisco Morales-RodriguezKwasi KwakwaEleonora KhabirovaGerda KildisiuteThomas R. W. OliverRonald R. de KrijgerMarry M. van den Heuvel-EibrinkFederico ComitaniAlice PiapiEva Bugallo-BlancoChristine ThevanesanChristina BurkeElena PrigmoreKirsty AmbridgeKenny RobertsFelipe A. Vieira BragaTim H. H. CoorensIgnacio Del ValleAnna Wilbrey-ClarkLira MamanovaGrant D. StewartVincent J. GnanapragasamDyanne RamplingNeil SebireNicholas ColemanLiz HookAnne WarrenMuzlifah HaniffaMarcel KoolStefan M. PfisterJohn C. AchermannXiaoling HeRoger A. BarkerAdam ShlienOmer A. BayraktarSarah A. TeichmannFrank C. HolstegeKerstin B. MeyerJarno DrostKarin StraathofSam BehjatiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati Single cell derived mRNA signals across human kidney tumors
description	Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
format	article
author	Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati
author_facet	Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati
author_sort	Matthew D. Young
title	Single cell derived mRNA signals across human kidney tumors
title_short	Single cell derived mRNA signals across human kidney tumors
title_full	Single cell derived mRNA signals across human kidney tumors
title_fullStr	Single cell derived mRNA signals across human kidney tumors
title_full_unstemmed	Single cell derived mRNA signals across human kidney tumors
title_sort	single cell derived mrna signals across human kidney tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
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Single cell derived mRNA signals across human kidney tumors

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