IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES

Abstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleuk...

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Autores principales:	T. V. Gavrilova, V. V. Chuprina, E. V. Davydova, Ju. I. Shilov, M. V. Chereshneva, V. A. Chereshnev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	myelopidum penetrating eye injury acute phase proteins cytokines complement system Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/07a86f8cced44906b84a890610e44cd2
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spelling	oai:doaj.org-article:07a86f8cced44906b84a890610e44cd22021-11-18T08:03:38ZIMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES1563-06252313-741X10.15789/1563-0625-2008-2-3-239-244https://doaj.org/article/07a86f8cced44906b84a890610e44cd22014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/158https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleukin (IL)-1β, IL-6, and activity of complement system were measured in peripheral blood, and concentrations of lactoferrin and IL-8 were determined in tears. An increase in lactoferrin, C-reactive protein, IL-1β, IL-8, and C5 complement component levels was detected during early post-traumatic period, as compared with data from the control group. As compared to effects of steroid and non-steroid anti-inflammatory drugs included into standard therapy, treatment with myelopidum has led to a more favorable clinical course of traumatic process, and resulted into more pronounced anti-inflammatory effect that was manifested by decrease in lactoferrin and C-reactive protein levels, reduction of IL-1β concentration, and C5 complement component activity. (Med. Immunol., 2008, vol. 10, N 2-3, pp 239-244).T. V. GavrilovaV. V. ChuprinaE. V. DavydovaJu. I. ShilovM. V. ChereshnevaV. A. ChereshnevSPb RAACIarticlemyelopidumpenetrating eye injuryacute phase proteinscytokinescomplement systemImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 239-244 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	myelopidum penetrating eye injury acute phase proteins cytokines complement system Immunologic diseases. Allergy RC581-607
spellingShingle	myelopidum penetrating eye injury acute phase proteins cytokines complement system Immunologic diseases. Allergy RC581-607 T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
description	Abstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleukin (IL)-1β, IL-6, and activity of complement system were measured in peripheral blood, and concentrations of lactoferrin and IL-8 were determined in tears. An increase in lactoferrin, C-reactive protein, IL-1β, IL-8, and C5 complement component levels was detected during early post-traumatic period, as compared with data from the control group. As compared to effects of steroid and non-steroid anti-inflammatory drugs included into standard therapy, treatment with myelopidum has led to a more favorable clinical course of traumatic process, and resulted into more pronounced anti-inflammatory effect that was manifested by decrease in lactoferrin and C-reactive protein levels, reduction of IL-1β concentration, and C5 complement component activity. (Med. Immunol., 2008, vol. 10, N 2-3, pp 239-244).
format	article
author	T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev
author_facet	T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev
author_sort	T. V. Gavrilova
title	IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
title_short	IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
title_full	IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
title_fullStr	IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
title_full_unstemmed	IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
title_sort	immunomodulatory action of myelopidum under its inclusion in complex therapy of patients with penetrating ocular injuries
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/07a86f8cced44906b84a890610e44cd2
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IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES

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