Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.

Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA tr...

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Autores principales:	Soroush Ghomashchi, Cari M Whyne, Tricia Chinnery, Fayez Habach, Margarete K Akens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07ac9c165465439bb90b04611412561d
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spelling	oai:doaj.org-article:07ac9c165465439bb90b04611412561d2021-12-02T20:04:41ZImpact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.1932-620310.1371/journal.pone.0256076https://doaj.org/article/07ac9c165465439bb90b04611412561d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256076https://doaj.org/toc/1932-6203Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.Soroush GhomashchiCari M WhyneTricia ChinneryFayez HabachMargarete K AkensPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256076 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soroush Ghomashchi Cari M Whyne Tricia Chinnery Fayez Habach Margarete K Akens Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
description	Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.
format	article
author	Soroush Ghomashchi Cari M Whyne Tricia Chinnery Fayez Habach Margarete K Akens
author_facet	Soroush Ghomashchi Cari M Whyne Tricia Chinnery Fayez Habach Margarete K Akens
author_sort	Soroush Ghomashchi
title	Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
title_short	Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
title_full	Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
title_fullStr	Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
title_full_unstemmed	Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.
title_sort	impact of radiofrequency ablation (rfa) on bone quality in a murine model of bone metastases.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/07ac9c165465439bb90b04611412561d
work_keys_str_mv	AT soroushghomashchi impactofradiofrequencyablationrfaonbonequalityinamurinemodelofbonemetastases AT carimwhyne impactofradiofrequencyablationrfaonbonequalityinamurinemodelofbonemetastases AT triciachinnery impactofradiofrequencyablationrfaonbonequalityinamurinemodelofbonemetastases AT fayezhabach impactofradiofrequencyablationrfaonbonequalityinamurinemodelofbonemetastases AT margaretekakens impactofradiofrequencyablationrfaonbonequalityinamurinemodelofbonemetastases
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Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases.

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