Magnetic particle imaging: current developments and future directions

Magnetic particle imaging: current developments and future directions

Nikolaos Panagiotopoulos,1 Robert L Duschka,1 Mandy Ahlborg,2 Gael Bringout,2 Christina Debbeler,2 Matthias Graeser,2 Christian Kaethner,2 Kerstin Lüdtke-Buzug,2 Hanne Medimagh,2 Jan Stelzner,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt,1 Julian Haegele1 1Clinic for Radio...

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Autores principales: Panagiotopoulos N, Duschka RL, Ahlborg M, Bringout G, Debbeler C, Graeser M, Kaethner C, Lüdtke-Buzug K, Medimagh H, Stelzner J, Buzug TM, Barkhausen J, Vogt FM, Haegele J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/07aec0e4c852477d8a5c83ff7e35b668
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spelling oai:doaj.org-article:07aec0e4c852477d8a5c83ff7e35b6682021-12-02T04:23:13ZMagnetic particle imaging: current developments and future directions1178-2013https://doaj.org/article/07aec0e4c852477d8a5c83ff7e35b6682015-04-01T00:00:00Zhttp://www.dovepress.com/magnetic-particle-imaging-current-developments-and-future-directions-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nikolaos Panagiotopoulos,1 Robert L Duschka,1 Mandy Ahlborg,2 Gael Bringout,2 Christina Debbeler,2 Matthias Graeser,2 Christian Kaethner,2 Kerstin Lüdtke-Buzug,2 Hanne Medimagh,2 Jan Stelzner,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt,1 Julian Haegele1 1Clinic for Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Campus Lübeck, 2Institute of Medical Engineering, University of Lübeck, Lübeck, Germany Abstract: Magnetic particle imaging (MPI) is a novel imaging method that was first proposed by Gleich and Weizenecker in 2005. Applying static and dynamic magnetic fields, MPI exploits the unique characteristics of superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs’ response allows a three-dimensional visualization of their distribution in space with a superb contrast, a very high temporal and good spatial resolution. Essentially, it is the SPIONs’ superparamagnetic characteristics, the fact that they are magnetically saturable, and the harmonic composition of the SPIONs’ response that make MPI possible at all. As SPIONs are the essential element of MPI, the development of customized nanoparticles is pursued with the greatest effort by many groups. Their objective is the creation of a SPION or a conglomerate of particles that will feature a much higher MPI performance than nanoparticles currently available commercially. A particle’s MPI performance and suitability is characterized by parameters such as the strength of its MPI signal, its biocompatibility, or its pharmacokinetics. Some of the most important adjuster bolts to tune them are the particles’ iron core and hydrodynamic diameter, their anisotropy, the composition of the particles’ suspension, and their coating. As a three-dimensional, real-time imaging modality that is free of ionizing radiation, MPI appears ideally suited for applications such as vascular imaging and interventions as well as cellular and targeted imaging. A number of different theories and technical approaches on the way to the actual implementation of the basic concept of MPI have been seen in the last few years. Research groups around the world are working on different scanner geometries, from closed bore systems to single-sided scanners, and use reconstruction methods that are either based on actual calibration measurements or on theoretical models. This review aims at giving an overview of current developments and future directions in MPI about a decade after its first appearance. Keywords: magnetic particle imaging, superparamagnetic iron oxide nanoparticles, magnetic particle spectrometer, peripheral nerve stimulation, cardiovascular interventionsPanagiotopoulos NDuschka RLAhlborg MBringout GDebbeler CGraeser MKaethner CLüdtke-Buzug KMedimagh HStelzner JBuzug TMBarkhausen JVogt FMHaegele JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3097-3114 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Panagiotopoulos N
Duschka RL
Ahlborg M
Bringout G
Debbeler C
Graeser M
Kaethner C
Lüdtke-Buzug K
Medimagh H
Stelzner J
Buzug TM
Barkhausen J
Vogt FM
Haegele J
Magnetic particle imaging: current developments and future directions
description Nikolaos Panagiotopoulos,1 Robert L Duschka,1 Mandy Ahlborg,2 Gael Bringout,2 Christina Debbeler,2 Matthias Graeser,2 Christian Kaethner,2 Kerstin Lüdtke-Buzug,2 Hanne Medimagh,2 Jan Stelzner,2 Thorsten M Buzug,2 Jörg Barkhausen,1 Florian M Vogt,1 Julian Haegele1 1Clinic for Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Campus Lübeck, 2Institute of Medical Engineering, University of Lübeck, Lübeck, Germany Abstract: Magnetic particle imaging (MPI) is a novel imaging method that was first proposed by Gleich and Weizenecker in 2005. Applying static and dynamic magnetic fields, MPI exploits the unique characteristics of superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs’ response allows a three-dimensional visualization of their distribution in space with a superb contrast, a very high temporal and good spatial resolution. Essentially, it is the SPIONs’ superparamagnetic characteristics, the fact that they are magnetically saturable, and the harmonic composition of the SPIONs’ response that make MPI possible at all. As SPIONs are the essential element of MPI, the development of customized nanoparticles is pursued with the greatest effort by many groups. Their objective is the creation of a SPION or a conglomerate of particles that will feature a much higher MPI performance than nanoparticles currently available commercially. A particle’s MPI performance and suitability is characterized by parameters such as the strength of its MPI signal, its biocompatibility, or its pharmacokinetics. Some of the most important adjuster bolts to tune them are the particles’ iron core and hydrodynamic diameter, their anisotropy, the composition of the particles’ suspension, and their coating. As a three-dimensional, real-time imaging modality that is free of ionizing radiation, MPI appears ideally suited for applications such as vascular imaging and interventions as well as cellular and targeted imaging. A number of different theories and technical approaches on the way to the actual implementation of the basic concept of MPI have been seen in the last few years. Research groups around the world are working on different scanner geometries, from closed bore systems to single-sided scanners, and use reconstruction methods that are either based on actual calibration measurements or on theoretical models. This review aims at giving an overview of current developments and future directions in MPI about a decade after its first appearance. Keywords: magnetic particle imaging, superparamagnetic iron oxide nanoparticles, magnetic particle spectrometer, peripheral nerve stimulation, cardiovascular interventions
format article
author Panagiotopoulos N
Duschka RL
Ahlborg M
Bringout G
Debbeler C
Graeser M
Kaethner C
Lüdtke-Buzug K
Medimagh H
Stelzner J
Buzug TM
Barkhausen J
Vogt FM
Haegele J
author_facet Panagiotopoulos N
Duschka RL
Ahlborg M
Bringout G
Debbeler C
Graeser M
Kaethner C
Lüdtke-Buzug K
Medimagh H
Stelzner J
Buzug TM
Barkhausen J
Vogt FM
Haegele J
author_sort Panagiotopoulos N
title Magnetic particle imaging: current developments and future directions
title_short Magnetic particle imaging: current developments and future directions
title_full Magnetic particle imaging: current developments and future directions
title_fullStr Magnetic particle imaging: current developments and future directions
title_full_unstemmed Magnetic particle imaging: current developments and future directions
title_sort magnetic particle imaging: current developments and future directions
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/07aec0e4c852477d8a5c83ff7e35b668
work_keys_str_mv AT panagiotopoulosn magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT duschkarl magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT ahlborgm magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT bringoutg magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT debbelerc magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT graeserm magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT kaethnerc magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT ludtkebuzugk magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT medimaghh magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT stelznerj magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT buzugtm magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT barkhausenj magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT vogtfm magneticparticleimagingcurrentdevelopmentsandfuturedirections
AT haegelej magneticparticleimagingcurrentdevelopmentsandfuturedirections
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