The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members

EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular...

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Autores principales:	Amrita Rai, Nathalie Bleimling, Ingrid R. Vetter, Roger S. Goody
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07b071be9df341b19ce4e9192524659d
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spelling	oai:doaj.org-article:07b071be9df341b19ce4e9192524659d2021-12-02T18:01:13ZThe mechanism of activation of the actin binding protein EHBP1 by Rab8 family members10.1038/s41467-020-17792-32041-1723https://doaj.org/article/07b071be9df341b19ce4e9192524659d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17792-3https://doaj.org/toc/2041-1723EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular complex which auto-inhibits actin binding.Amrita RaiNathalie BleimlingIngrid R. VetterRoger S. GoodyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amrita Rai Nathalie Bleimling Ingrid R. Vetter Roger S. Goody The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
description	EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular complex which auto-inhibits actin binding.
format	article
author	Amrita Rai Nathalie Bleimling Ingrid R. Vetter Roger S. Goody
author_facet	Amrita Rai Nathalie Bleimling Ingrid R. Vetter Roger S. Goody
author_sort	Amrita Rai
title	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
title_short	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
title_full	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
title_fullStr	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
title_full_unstemmed	The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
title_sort	mechanism of activation of the actin binding protein ehbp1 by rab8 family members
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/07b071be9df341b19ce4e9192524659d
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The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members

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