The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

We know that most splicing reactions take place co-transcriptionally, but how the transcription machinery facilitate splicing of introns is unknown. Here the authors show that the 5′ splice site remains associated with the transcription machinery during intron synthesis through U1 snRNP, providing a...

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Autores principales:	Yodfat Leader, Galit Lev Maor, Matan Sorek, Ronna Shayevitch, Maram Hussein, Ofir Hameiri, Luna Tammer, Jonathan Zonszain, Ifat Keydar, Dror Hollander, Eran Meshorer, Gil Ast
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07b1b9cd06be45f09e95094071279256
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spelling	oai:doaj.org-article:07b1b9cd06be45f09e950940712792562021-12-02T16:23:43ZThe upstream 5′ splice site remains associated to the transcription machinery during intron synthesis10.1038/s41467-021-24774-62041-1723https://doaj.org/article/07b1b9cd06be45f09e950940712792562021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24774-6https://doaj.org/toc/2041-1723We know that most splicing reactions take place co-transcriptionally, but how the transcription machinery facilitate splicing of introns is unknown. Here the authors show that the 5′ splice site remains associated with the transcription machinery during intron synthesis through U1 snRNP, providing a basis for the rapid splicing reaction of introns.Yodfat LeaderGalit Lev MaorMatan SorekRonna ShayevitchMaram HusseinOfir HameiriLuna TammerJonathan ZonszainIfat KeydarDror HollanderEran MeshorerGil AstNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yodfat Leader Galit Lev Maor Matan Sorek Ronna Shayevitch Maram Hussein Ofir Hameiri Luna Tammer Jonathan Zonszain Ifat Keydar Dror Hollander Eran Meshorer Gil Ast The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
description	We know that most splicing reactions take place co-transcriptionally, but how the transcription machinery facilitate splicing of introns is unknown. Here the authors show that the 5′ splice site remains associated with the transcription machinery during intron synthesis through U1 snRNP, providing a basis for the rapid splicing reaction of introns.
format	article
author	Yodfat Leader Galit Lev Maor Matan Sorek Ronna Shayevitch Maram Hussein Ofir Hameiri Luna Tammer Jonathan Zonszain Ifat Keydar Dror Hollander Eran Meshorer Gil Ast
author_facet	Yodfat Leader Galit Lev Maor Matan Sorek Ronna Shayevitch Maram Hussein Ofir Hameiri Luna Tammer Jonathan Zonszain Ifat Keydar Dror Hollander Eran Meshorer Gil Ast
author_sort	Yodfat Leader
title	The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
title_short	The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
title_full	The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
title_fullStr	The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
title_full_unstemmed	The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
title_sort	upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07b1b9cd06be45f09e95094071279256
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The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

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