Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey
ABSTRACT The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/07b24d6944e544babe99d5121dbd3b3b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:07b24d6944e544babe99d5121dbd3b3b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:07b24d6944e544babe99d5121dbd3b3b2021-11-15T15:29:16ZMulticenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey10.1128/mSphere.00060-202379-5042https://doaj.org/article/07b24d6944e544babe99d5121dbd3b3b2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00060-20https://doaj.org/toc/2379-5042ABSTRACT The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In 2011, PCV-7 was replaced with PCV-13. Meningococcal vaccines have not yet been included in Turkish NIP. This prospective study comprised 27 hospitals located in seven regions of Turkey and represented 45% of the population. Children aged between 1 month and 18 years who were hospitalized with suspected meningitis were included. Cerebrospinal fluid (CSF) samples were collected, and bacterial identification was made according to the multiplex PCR assay results. During the study period, 994 children were hospitalized for suspected meningitis, and Hib (n = 3, 2.4%), S. pneumoniae (n = 33, 26.4%), and Neisseria meningitidis (n = 89, 71%) were detected in 125 samples. The most common meningococcal serogroup was MenB. Serogroup W comprised 13.9% (n = 5) and 7.5% (n = 4) of the meningococci in 2015 to 2016 and 2017 to 2018, respectively. Serogroup C was not detected. There were four deaths in the study; one was a pneumococcus case, and the others were serogroup B meningococcus cases. The epidemiology of meningococcal diseases has varied over time in Turkey. Differing from the previous surveillance periods, MenB was the most common serogroup in the 2015-to-2018 period. Meningococcal epidemiology is so dynamic that, for vaccination policies, close monitoring is crucial. IMPORTANCE Acute bacterial meningitis (ABM) is one of the most common life-threatening infections in children. The incidence and prevalence of ABM vary both geographically and temporally; therefore, surveillance systems are necessary to determine the accurate burden of ABM. The Turkish Meningitis Surveillance Group has been performing a hospital-based meningitis surveillance study since 2005 across several regions in Turkey. Meningococcus was the major ABM-causing agent during the 2015-to-2018 period, during which MenB was the dominant serogroup.Mehmet CeyhanYasemin OzsurekciSevgen Tanır BasaranogluNezahat GurlerEnes SaliMelike Keser EmirogluFatma Nur OzNursen BeletMurat DumanEmel UlusoyZafer KurugolHasan TezerAslinur Ozkaya ParlakayEner Cagri DinleyiciUmit CelikSolmaz CelebiAhmet Faik OnerMehmet Ali SolmazAdem KarbuzNevin HatipogluIlker DevrimIlknur CaglarSefika Elmas BozdemirEmine KocabasOzlem Ozgur GundesliogluMurat SutcuOzge Metin AkcanNecdet KuyucuFesih AktarSoner Sertan KaraHavva Ozlem Altay AkisogluNilden TuygunZeynep Diyar Tamburaci UsluEda Karadag OncelCihangul BayhanAli Bulent CengizAmerican Society for MicrobiologyarticlemeningitisTurkeyN. meningitidisS. pneumoniaeHibepidemiologyMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
meningitis Turkey N. meningitidis S. pneumoniae Hib epidemiology Microbiology QR1-502 |
| spellingShingle |
meningitis Turkey N. meningitidis S. pneumoniae Hib epidemiology Microbiology QR1-502 Mehmet Ceyhan Yasemin Ozsurekci Sevgen Tanır Basaranoglu Nezahat Gurler Enes Sali Melike Keser Emiroglu Fatma Nur Oz Nursen Belet Murat Duman Emel Ulusoy Zafer Kurugol Hasan Tezer Aslinur Ozkaya Parlakay Ener Cagri Dinleyici Umit Celik Solmaz Celebi Ahmet Faik Oner Mehmet Ali Solmaz Adem Karbuz Nevin Hatipoglu Ilker Devrim Ilknur Caglar Sefika Elmas Bozdemir Emine Kocabas Ozlem Ozgur Gundeslioglu Murat Sutcu Ozge Metin Akcan Necdet Kuyucu Fesih Aktar Soner Sertan Kara Havva Ozlem Altay Akisoglu Nilden Tuygun Zeynep Diyar Tamburaci Uslu Eda Karadag Oncel Cihangul Bayhan Ali Bulent Cengiz Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| description |
ABSTRACT The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In 2011, PCV-7 was replaced with PCV-13. Meningococcal vaccines have not yet been included in Turkish NIP. This prospective study comprised 27 hospitals located in seven regions of Turkey and represented 45% of the population. Children aged between 1 month and 18 years who were hospitalized with suspected meningitis were included. Cerebrospinal fluid (CSF) samples were collected, and bacterial identification was made according to the multiplex PCR assay results. During the study period, 994 children were hospitalized for suspected meningitis, and Hib (n = 3, 2.4%), S. pneumoniae (n = 33, 26.4%), and Neisseria meningitidis (n = 89, 71%) were detected in 125 samples. The most common meningococcal serogroup was MenB. Serogroup W comprised 13.9% (n = 5) and 7.5% (n = 4) of the meningococci in 2015 to 2016 and 2017 to 2018, respectively. Serogroup C was not detected. There were four deaths in the study; one was a pneumococcus case, and the others were serogroup B meningococcus cases. The epidemiology of meningococcal diseases has varied over time in Turkey. Differing from the previous surveillance periods, MenB was the most common serogroup in the 2015-to-2018 period. Meningococcal epidemiology is so dynamic that, for vaccination policies, close monitoring is crucial. IMPORTANCE Acute bacterial meningitis (ABM) is one of the most common life-threatening infections in children. The incidence and prevalence of ABM vary both geographically and temporally; therefore, surveillance systems are necessary to determine the accurate burden of ABM. The Turkish Meningitis Surveillance Group has been performing a hospital-based meningitis surveillance study since 2005 across several regions in Turkey. Meningococcus was the major ABM-causing agent during the 2015-to-2018 period, during which MenB was the dominant serogroup. |
| format |
article |
| author |
Mehmet Ceyhan Yasemin Ozsurekci Sevgen Tanır Basaranoglu Nezahat Gurler Enes Sali Melike Keser Emiroglu Fatma Nur Oz Nursen Belet Murat Duman Emel Ulusoy Zafer Kurugol Hasan Tezer Aslinur Ozkaya Parlakay Ener Cagri Dinleyici Umit Celik Solmaz Celebi Ahmet Faik Oner Mehmet Ali Solmaz Adem Karbuz Nevin Hatipoglu Ilker Devrim Ilknur Caglar Sefika Elmas Bozdemir Emine Kocabas Ozlem Ozgur Gundeslioglu Murat Sutcu Ozge Metin Akcan Necdet Kuyucu Fesih Aktar Soner Sertan Kara Havva Ozlem Altay Akisoglu Nilden Tuygun Zeynep Diyar Tamburaci Uslu Eda Karadag Oncel Cihangul Bayhan Ali Bulent Cengiz |
| author_facet |
Mehmet Ceyhan Yasemin Ozsurekci Sevgen Tanır Basaranoglu Nezahat Gurler Enes Sali Melike Keser Emiroglu Fatma Nur Oz Nursen Belet Murat Duman Emel Ulusoy Zafer Kurugol Hasan Tezer Aslinur Ozkaya Parlakay Ener Cagri Dinleyici Umit Celik Solmaz Celebi Ahmet Faik Oner Mehmet Ali Solmaz Adem Karbuz Nevin Hatipoglu Ilker Devrim Ilknur Caglar Sefika Elmas Bozdemir Emine Kocabas Ozlem Ozgur Gundeslioglu Murat Sutcu Ozge Metin Akcan Necdet Kuyucu Fesih Aktar Soner Sertan Kara Havva Ozlem Altay Akisoglu Nilden Tuygun Zeynep Diyar Tamburaci Uslu Eda Karadag Oncel Cihangul Bayhan Ali Bulent Cengiz |
| author_sort |
Mehmet Ceyhan |
| title |
Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| title_short |
Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| title_full |
Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| title_fullStr |
Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| title_full_unstemmed |
Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of <named-content content-type="genus-species">Neisseria meningitidis</named-content>, <named-content content-type="genus-species">Haemophilus influenzae</named-content> Type b, and <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> during 2015 to 2018 in Turkey |
| title_sort |
multicenter hospital-based prospective surveillance study of bacterial agents causing meningitis and seroprevalence of different serogroups of <named-content content-type="genus-species">neisseria meningitidis</named-content>, <named-content content-type="genus-species">haemophilus influenzae</named-content> type b, and <named-content content-type="genus-species">streptococcus pneumoniae</named-content> during 2015 to 2018 in turkey |
| publisher |
American Society for Microbiology |
| publishDate |
2020 |
| url |
https://doaj.org/article/07b24d6944e544babe99d5121dbd3b3b |
| work_keys_str_mv |
AT mehmetceyhan multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT yaseminozsurekci multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT sevgentanırbasaranoglu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT nezahatgurler multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT enessali multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT melikekeseremiroglu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT fatmanuroz multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT nursenbelet multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT muratduman multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT emelulusoy multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT zaferkurugol multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT hasantezer multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT aslinurozkayaparlakay multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT enercagridinleyici multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT umitcelik multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT solmazcelebi multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ahmetfaikoner multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT mehmetalisolmaz multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ademkarbuz multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT nevinhatipoglu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ilkerdevrim multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ilknurcaglar multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT sefikaelmasbozdemir multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT eminekocabas multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ozlemozgurgundeslioglu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT muratsutcu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT ozgemetinakcan multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT necdetkuyucu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT fesihaktar multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT sonersertankara multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT havvaozlemaltayakisoglu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT nildentuygun multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT zeynepdiyartamburaciuslu multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT edakaradagoncel multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT cihangulbayhan multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed AT alibulentcengiz multicenterhospitalbasedprospectivesurveillancestudyofbacterialagentscausingmeningitisandseroprevalenceofdifferentserogroupsofnamedcontentcontenttypegenusspeciesneisseriameningitidisnamedcontentnamedcontentcontenttypegenusspecieshaemophilusinfluenzaenamed |
| _version_ |
1718427867885338624 |