EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

We observed sixty patients with allergic bronchial asthma (ABA) and 54 with non-allergic bronchial asthma (NABA). Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectivel...

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Autores principales:	V. V. Lim, L. N. Sorokina, V. N. Mineev, M. A. Nyoma, V. I. Trofimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma socs proteins socs3 socs5 expression mononuclear cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/07b31ae2dd454c28a1e58b9fa19d71b3
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spelling	oai:doaj.org-article:07b31ae2dd454c28a1e58b9fa19d71b32021-11-18T08:03:43ZEXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2014-2-149-154https://doaj.org/article/07b31ae2dd454c28a1e58b9fa19d71b32014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/680https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe observed sixty patients with allergic bronchial asthma (ABA) and 54 with non-allergic bronchial asthma (NABA). Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form), a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA), may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.V. V. LimL. N. SorokinaV. N. MineevM. A. NyomaV. I. TrofimovSPb RAACIarticlebronchial asthmasocs proteinssocs3socs5expressionmononuclear cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 149-154 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma socs proteins socs3 socs5 expression mononuclear cells Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma socs proteins socs3 socs5 expression mononuclear cells Immunologic diseases. Allergy RC581-607 V. V. Lim L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
description	We observed sixty patients with allergic bronchial asthma (ABA) and 54 with non-allergic bronchial asthma (NABA). Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form), a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA), may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.
format	article
author	V. V. Lim L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov
author_facet	V. V. Lim L. N. Sorokina V. N. Mineev M. A. Nyoma V. I. Trofimov
author_sort	V. V. Lim
title	EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_short	EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_full	EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_fullStr	EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_full_unstemmed	EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_sort	expression of socs3 and socs5 mrnas in peripheral blood mononuclears from the patients with bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/07b31ae2dd454c28a1e58b9fa19d71b3
work_keys_str_mv	AT vvlim expressionofsocs3andsocs5mrnasinperipheralbloodmononuclearsfromthepatientswithbronchialasthma AT lnsorokina expressionofsocs3andsocs5mrnasinperipheralbloodmononuclearsfromthepatientswithbronchialasthma AT vnmineev expressionofsocs3andsocs5mrnasinperipheralbloodmononuclearsfromthepatientswithbronchialasthma AT manyoma expressionofsocs3andsocs5mrnasinperipheralbloodmononuclearsfromthepatientswithbronchialasthma AT vitrofimov expressionofsocs3andsocs5mrnasinperipheralbloodmononuclearsfromthepatientswithbronchialasthma
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EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

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