Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by interaction with core-located tumour cells.
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Nature Portfolio
2020
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oai:doaj.org-article:07b5f2bb5b4a4838a58f12fd8d7ba3c52021-12-02T18:33:51ZGlioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy10.1038/s41467-020-18189-y2041-1723https://doaj.org/article/07b5f2bb5b4a4838a58f12fd8d7ba3c52020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18189-yhttps://doaj.org/toc/2041-1723Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by interaction with core-located tumour cells.Soniya BastolaMarat S. PavlyukovDaisuke YamashitaSadashib GhoshHeejin ChoNoritaka KagayaZhuo ZhangMutsuko MinataYeri LeeHirokazu SadahiroShinobu YamaguchiSvetlana KomarovaEddy YangJames MarkertLouis B. NaborsKrishna BhatJames LeeQin ChenDavid K. CrossmanKazuo Shin-YaDo-Hyun NamIchiro NakanoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Soniya Bastola Marat S. Pavlyukov Daisuke Yamashita Sadashib Ghosh Heejin Cho Noritaka Kagaya Zhuo Zhang Mutsuko Minata Yeri Lee Hirokazu Sadahiro Shinobu Yamaguchi Svetlana Komarova Eddy Yang James Markert Louis B. Nabors Krishna Bhat James Lee Qin Chen David K. Crossman Kazuo Shin-Ya Do-Hyun Nam Ichiro Nakano Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| description |
Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by interaction with core-located tumour cells. |
| format |
article |
| author |
Soniya Bastola Marat S. Pavlyukov Daisuke Yamashita Sadashib Ghosh Heejin Cho Noritaka Kagaya Zhuo Zhang Mutsuko Minata Yeri Lee Hirokazu Sadahiro Shinobu Yamaguchi Svetlana Komarova Eddy Yang James Markert Louis B. Nabors Krishna Bhat James Lee Qin Chen David K. Crossman Kazuo Shin-Ya Do-Hyun Nam Ichiro Nakano |
| author_facet |
Soniya Bastola Marat S. Pavlyukov Daisuke Yamashita Sadashib Ghosh Heejin Cho Noritaka Kagaya Zhuo Zhang Mutsuko Minata Yeri Lee Hirokazu Sadahiro Shinobu Yamaguchi Svetlana Komarova Eddy Yang James Markert Louis B. Nabors Krishna Bhat James Lee Qin Chen David K. Crossman Kazuo Shin-Ya Do-Hyun Nam Ichiro Nakano |
| author_sort |
Soniya Bastola |
| title |
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| title_short |
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| title_full |
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| title_fullStr |
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| title_full_unstemmed |
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| title_sort |
glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/07b5f2bb5b4a4838a58f12fd8d7ba3c5 |
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