Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness

Abstract Clinical diagnosis of patients with prolonged disorders of consciousness is very challenging. As spontaneous eye blink rate (EBR) is reliably correlated with cognitive activity in healthy individuals, we investigated whether EBR could serve as a marker of patients’ level of consciousness. W...

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Autores principales:	Alfonso Magliacano, Martin Rosenfelder, Nina Hieber, Andreas Bender, Anna Estraneo, Luigi Trojano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07b76a9a607b46a9a5273e3d98fdd1c5
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spelling	oai:doaj.org-article:07b76a9a607b46a9a5273e3d98fdd1c52021-11-21T12:16:28ZSpontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness10.1038/s41598-021-01858-32045-2322https://doaj.org/article/07b76a9a607b46a9a5273e3d98fdd1c52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01858-3https://doaj.org/toc/2045-2322Abstract Clinical diagnosis of patients with prolonged disorders of consciousness is very challenging. As spontaneous eye blink rate (EBR) is reliably correlated with cognitive activity in healthy individuals, we investigated whether EBR could serve as a marker of patients’ level of consciousness. We assessed ten patients in prolonged Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS; three females; mean age = 50.3 ± 17.8 years) and fourteen patients in Minimally Conscious State (MCS; three females; mean age = 52.9 ± 17.5 years) at their admission to a rehabilitation unit after the acute phase. During two separate 3-min rest conditions, we recorded patients’ EBR by integrating on-line visual and off-line electro-oculographic count. We also assessed EBR during two auditory oddball tasks, i.e. passive listening and active counting of target tones in a sub-group of patients. EBR was significantly higher in MCS than in VS/UWS; moreover, EBR positively correlated with a validated index of responsiveness derived from the Coma Recovery Scale-Revised. Patients’ mean EBR showed no significant differences within sessions and across experimental conditions of the oddball task, in both VS/UWS and MCS. Our findings suggest that, at least in the post-acute phase, observing patients’ EBR for 3 min at rest could help to discriminate between VS/UWS and MCS, improving accuracy of clinical diagnosis.Alfonso MagliacanoMartin RosenfelderNina HieberAndreas BenderAnna EstraneoLuigi TrojanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alfonso Magliacano Martin Rosenfelder Nina Hieber Andreas Bender Anna Estraneo Luigi Trojano Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
description	Abstract Clinical diagnosis of patients with prolonged disorders of consciousness is very challenging. As spontaneous eye blink rate (EBR) is reliably correlated with cognitive activity in healthy individuals, we investigated whether EBR could serve as a marker of patients’ level of consciousness. We assessed ten patients in prolonged Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS; three females; mean age = 50.3 ± 17.8 years) and fourteen patients in Minimally Conscious State (MCS; three females; mean age = 52.9 ± 17.5 years) at their admission to a rehabilitation unit after the acute phase. During two separate 3-min rest conditions, we recorded patients’ EBR by integrating on-line visual and off-line electro-oculographic count. We also assessed EBR during two auditory oddball tasks, i.e. passive listening and active counting of target tones in a sub-group of patients. EBR was significantly higher in MCS than in VS/UWS; moreover, EBR positively correlated with a validated index of responsiveness derived from the Coma Recovery Scale-Revised. Patients’ mean EBR showed no significant differences within sessions and across experimental conditions of the oddball task, in both VS/UWS and MCS. Our findings suggest that, at least in the post-acute phase, observing patients’ EBR for 3 min at rest could help to discriminate between VS/UWS and MCS, improving accuracy of clinical diagnosis.
format	article
author	Alfonso Magliacano Martin Rosenfelder Nina Hieber Andreas Bender Anna Estraneo Luigi Trojano
author_facet	Alfonso Magliacano Martin Rosenfelder Nina Hieber Andreas Bender Anna Estraneo Luigi Trojano
author_sort	Alfonso Magliacano
title	Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
title_short	Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
title_full	Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
title_fullStr	Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
title_full_unstemmed	Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
title_sort	spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07b76a9a607b46a9a5273e3d98fdd1c5
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Spontaneous eye blinking as a diagnostic marker in prolonged disorders of consciousness

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