$Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa$
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Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa

Among a growing body of literature in global oncology, several articles project increased cost savings and radiotherapy access by adopting hypofractionated radiotherapy (HFRT) in low- and middle-income countries (LMICs) like those in Africa. Clinical trials in Europe and the USA have demonstrated HF...

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Autores principales:	William Swanson, Richard Ndi Samba, Michael Lavelle, Ahmed Elzawawy, Erno Sajo, Wilfred Ngwa, Luca Incrocci
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prostate cancer hypofractionation radiotherapy guidelines Africa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/07b99f0321d747e88d137ea6646b4758
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spelling	oai:doaj.org-article:07b99f0321d747e88d137ea6646b47582021-12-01T23:57:56ZPractical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa2234-943X10.3389/fonc.2021.725103https://doaj.org/article/07b99f0321d747e88d137ea6646b47582021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.725103/fullhttps://doaj.org/toc/2234-943XAmong a growing body of literature in global oncology, several articles project increased cost savings and radiotherapy access by adopting hypofractionated radiotherapy (HFRT) in low- and middle-income countries (LMICs) like those in Africa. Clinical trials in Europe and the USA have demonstrated HFRT to be non-inferior to conventional radiotherapy for eligible patients with several cancers, including prostate cancer. This could be a highly recommended option to battle a severely large and growing cancer burden in resource-limited regions. However, a level of implementation research may be needed in limited resource-settings like in Africa. In this article, we present a list of evidence-based recommendations to practice HFRT on eligible prostate cancer patients. As literature on HFRT is still developing, these guidelines were compiled from review of several clinical trials and professionally accredited material with minimal resource requirements in mind. HFRT guidelines presented here include patient eligibility, prescription dose schedules, treatment planning and delivery techniques, and quality assurance procedures. The article provides recommendations for both moderately hypofractionated (2.4-3.4Gy per fraction) and ultrahypofractionated (5Gy or more per fraction) radiation therapy when administered by 3D-Conformal Radiotherapy, Intensity Modulated Radiation Therapy, or Image-Guided Radiotherapy. In each case radiation oncology health professionals must make the ultimate judgment to ensure safety as more LMIC centers adopt HFRT to combat the growing scourge of cancer.William SwansonWilliam SwansonRichard Ndi SambaMichael LavelleAhmed ElzawawyErno SajoWilfred NgwaWilfred NgwaLuca IncrocciFrontiers Media S.A.articleprostate cancerhypofractionationradiotherapyguidelinesAfricaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer hypofractionation radiotherapy guidelines Africa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer hypofractionation radiotherapy guidelines Africa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 William Swanson William Swanson Richard Ndi Samba Michael Lavelle Ahmed Elzawawy Erno Sajo Wilfred Ngwa Wilfred Ngwa Luca Incrocci Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
description	Among a growing body of literature in global oncology, several articles project increased cost savings and radiotherapy access by adopting hypofractionated radiotherapy (HFRT) in low- and middle-income countries (LMICs) like those in Africa. Clinical trials in Europe and the USA have demonstrated HFRT to be non-inferior to conventional radiotherapy for eligible patients with several cancers, including prostate cancer. This could be a highly recommended option to battle a severely large and growing cancer burden in resource-limited regions. However, a level of implementation research may be needed in limited resource-settings like in Africa. In this article, we present a list of evidence-based recommendations to practice HFRT on eligible prostate cancer patients. As literature on HFRT is still developing, these guidelines were compiled from review of several clinical trials and professionally accredited material with minimal resource requirements in mind. HFRT guidelines presented here include patient eligibility, prescription dose schedules, treatment planning and delivery techniques, and quality assurance procedures. The article provides recommendations for both moderately hypofractionated (2.4-3.4Gy per fraction) and ultrahypofractionated (5Gy or more per fraction) radiation therapy when administered by 3D-Conformal Radiotherapy, Intensity Modulated Radiation Therapy, or Image-Guided Radiotherapy. In each case radiation oncology health professionals must make the ultimate judgment to ensure safety as more LMIC centers adopt HFRT to combat the growing scourge of cancer.
format	article
author	William Swanson William Swanson Richard Ndi Samba Michael Lavelle Ahmed Elzawawy Erno Sajo Wilfred Ngwa Wilfred Ngwa Luca Incrocci
author_facet	William Swanson William Swanson Richard Ndi Samba Michael Lavelle Ahmed Elzawawy Erno Sajo Wilfred Ngwa Wilfred Ngwa Luca Incrocci
author_sort	William Swanson
title	Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
title_short	Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
title_full	Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
title_fullStr	Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
title_full_unstemmed	Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa
title_sort	practical guidelines on implementing hypofractionated radiotherapy for prostate cancer in africa
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/07b99f0321d747e88d137ea6646b4758
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Practical Guidelines on Implementing Hypofractionated Radiotherapy for Prostate Cancer in Africa

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