Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Suppression of Ribosome Biogenesis by Targeting WD Repeat Domain 12 (WDR12) Inhibits Glioma Stem-Like Cell Growth

Glioma stem-like cells (GSCs) are a subset of tumor cells that initiate malignant growth and promote the therapeutic resistance of glioblastoma, the most lethal primary brain tumor. Ribosome biogenesis is an essential cellular process to maintain cell growth, but its regulatory mechanism in GSCs rem...

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Bibliographic Details
Main Authors: Lanjuan Mi, Qinghui Qi, Haowen Ran, Lishu Chen, Da Li, Dake Xiao, Jiaqi Wu, Yan Cai, Songyang Zhang, Yuanyuan Li, Bohan Li, Jiong Xie, Haohao Huang, Tao Li, Tao Zhou, Ailing Li, Ji Qi, Fangye Li, Jianghong Man
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
glioblastoma (GBM)
glioma stem-like cells (GSCs)
WDR12
ribosome
therapy of glioblastoma
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/07b9ddd034f242f78a2afe360ac3c128
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https://doaj.org/article/07b9ddd034f242f78a2afe360ac3c128

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