Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

Abstract Acute myocardial infarction and chronic heart failure rank among the major causes of morbidity and mortality worldwide. Except for heart transplantation, current therapy options only treat the symptoms but do not cure the disease. Stem cell-based therapies represent a possible paradigm shif...

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Autores principales:	Elena Cambria, Francesco S. Pasqualini, Petra Wolint, Julia Günter, Julia Steiger, Annina Bopp, Simon P. Hoerstrup, Maximilian Y. Emmert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/07ba522561994afbb43f824efa0bb64a
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spelling	oai:doaj.org-article:07ba522561994afbb43f824efa0bb64a2021-12-02T14:22:14ZTranslational cardiac stem cell therapy: advancing from first-generation to next-generation cell types10.1038/s41536-017-0024-12057-3995https://doaj.org/article/07ba522561994afbb43f824efa0bb64a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0024-1https://doaj.org/toc/2057-3995Abstract Acute myocardial infarction and chronic heart failure rank among the major causes of morbidity and mortality worldwide. Except for heart transplantation, current therapy options only treat the symptoms but do not cure the disease. Stem cell-based therapies represent a possible paradigm shift for cardiac repair. However, most of the first-generation approaches displayed heterogeneous clinical outcomes regarding efficacy. Stemming from the desire to closely match the target organ, second-generation cell types were introduced and rapidly moved from bench to bedside. Unfortunately, debates remain around the benefit of stem cell therapy, optimal trial design parameters, and the ideal cell type. Aiming at highlighting controversies, this article provides a critical overview of the translation of first-generation and second-generation cell types. It further emphasizes the importance of understanding the mechanisms of cardiac repair and the lessons learned from first-generation trials, in order to improve cell-based therapies and to potentially finally implement cell-free therapies.Elena CambriaFrancesco S. PasqualiniPetra WolintJulia GünterJulia SteigerAnnina BoppSimon P. HoerstrupMaximilian Y. EmmertNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Elena Cambria Francesco S. Pasqualini Petra Wolint Julia Günter Julia Steiger Annina Bopp Simon P. Hoerstrup Maximilian Y. Emmert Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
description	Abstract Acute myocardial infarction and chronic heart failure rank among the major causes of morbidity and mortality worldwide. Except for heart transplantation, current therapy options only treat the symptoms but do not cure the disease. Stem cell-based therapies represent a possible paradigm shift for cardiac repair. However, most of the first-generation approaches displayed heterogeneous clinical outcomes regarding efficacy. Stemming from the desire to closely match the target organ, second-generation cell types were introduced and rapidly moved from bench to bedside. Unfortunately, debates remain around the benefit of stem cell therapy, optimal trial design parameters, and the ideal cell type. Aiming at highlighting controversies, this article provides a critical overview of the translation of first-generation and second-generation cell types. It further emphasizes the importance of understanding the mechanisms of cardiac repair and the lessons learned from first-generation trials, in order to improve cell-based therapies and to potentially finally implement cell-free therapies.
format	article
author	Elena Cambria Francesco S. Pasqualini Petra Wolint Julia Günter Julia Steiger Annina Bopp Simon P. Hoerstrup Maximilian Y. Emmert
author_facet	Elena Cambria Francesco S. Pasqualini Petra Wolint Julia Günter Julia Steiger Annina Bopp Simon P. Hoerstrup Maximilian Y. Emmert
author_sort	Elena Cambria
title	Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
title_short	Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
title_full	Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
title_fullStr	Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
title_full_unstemmed	Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
title_sort	translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/07ba522561994afbb43f824efa0bb64a
work_keys_str_mv	AT elenacambria translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT francescospasqualini translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT petrawolint translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT juliagunter translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT juliasteiger translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT anninabopp translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT simonphoerstrup translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes AT maximilianyemmert translationalcardiacstemcelltherapyadvancingfromfirstgenerationtonextgenerationcelltypes
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Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

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