Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

Xin Huang,1,2,* Hai-Jun Li,3,* Ying Zhang,1 De-Chang Peng,3 Pei-Hong Hu,1 Yu-Lin Zhong,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujian...

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Autores principales:	Huang X, Li HJ, Zhang Y, Peng DC, Hu PH, Zhong YL, Zhou FQ, Shao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/07ba8f14721f47fc97fa14aec1fe08da
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spelling	oai:doaj.org-article:07ba8f14721f47fc97fa14aec1fe08da2021-12-02T08:41:37ZMicrostructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study1178-2021https://doaj.org/article/07ba8f14721f47fc97fa14aec1fe08da2016-08-01T00:00:00Zhttps://www.dovepress.com/microstructural-changes-of-whole-brain-in-patients-with-comitant-strab-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xin Huang,1,2,* Hai-Jun Li,3,* Ying Zhang,1 De-Chang Peng,3 Pei-Hong Hu,1 Yu-Lin Zhong,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this work Objective: The aim of this study was to investigate the fractional anisotropy (FA) and mean diffusivity (MD) using a diffusion tensor imaging technique and whole-brain voxel-based analysis in patients with comitant strabismus.Patients and methods: A total of 19 (nine males and ten females) patients with comitant strabismus and 19 age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging examination. Imaging data were analyzed using two-sample t-tests to identify group differences in FA and MD values. Patients with comitant strabismus were distinguishable from HCs by receiver operating characteristic curves.Results: Compared with HCs, patients with comitant strabismus exhibited significantly decreased FA values in the brain regions of the left superior temporal gyrus and increased values in the bilateral medial frontal gyrus, right globus pallidus/brainstem, and bilateral precuneus. Meanwhile, MD value was significantly reduced in the brain regions of the bilateral cerebellum posterior lobe and left middle frontal gyrus but increased in the brain regions of the right middle frontal gyrus and left anterior cingulate.Conclusion: These results suggest significant brain abnormalities in comitant strabismus, which may underlie the pathologic mechanisms of fusion defects and ocular motility disorders in patients with comitant strabismus. Keywords: comitant strabismus, diffusion tensor imaging, mean diffusivity, fractional anisotropy, resting stateHuang XLi HJZhang YPeng DCHu PHZhong YLZhou FQShao YDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2007-2014 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Li HJ Zhang Y Peng DC Hu PH Zhong YL Zhou FQ Shao Y Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
description	Xin Huang,1,2,* Hai-Jun Li,3,* Ying Zhang,1 De-Chang Peng,3 Pei-Hong Hu,1 Yu-Lin Zhong,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this work Objective: The aim of this study was to investigate the fractional anisotropy (FA) and mean diffusivity (MD) using a diffusion tensor imaging technique and whole-brain voxel-based analysis in patients with comitant strabismus.Patients and methods: A total of 19 (nine males and ten females) patients with comitant strabismus and 19 age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging examination. Imaging data were analyzed using two-sample t-tests to identify group differences in FA and MD values. Patients with comitant strabismus were distinguishable from HCs by receiver operating characteristic curves.Results: Compared with HCs, patients with comitant strabismus exhibited significantly decreased FA values in the brain regions of the left superior temporal gyrus and increased values in the bilateral medial frontal gyrus, right globus pallidus/brainstem, and bilateral precuneus. Meanwhile, MD value was significantly reduced in the brain regions of the bilateral cerebellum posterior lobe and left middle frontal gyrus but increased in the brain regions of the right middle frontal gyrus and left anterior cingulate.Conclusion: These results suggest significant brain abnormalities in comitant strabismus, which may underlie the pathologic mechanisms of fusion defects and ocular motility disorders in patients with comitant strabismus. Keywords: comitant strabismus, diffusion tensor imaging, mean diffusivity, fractional anisotropy, resting state
format	article
author	Huang X Li HJ Zhang Y Peng DC Hu PH Zhong YL Zhou FQ Shao Y
author_facet	Huang X Li HJ Zhang Y Peng DC Hu PH Zhong YL Zhou FQ Shao Y
author_sort	Huang X
title	Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
title_short	Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
title_full	Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
title_fullStr	Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
title_full_unstemmed	Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
title_sort	microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/07ba8f14721f47fc97fa14aec1fe08da
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Microstructural changes of whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study

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