Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study

Abstract The purpose of our study was to evaluate the effect of surgery on the survival and prognosis of patients with multifocal intrahepatic cholangiocarcinoma (ICCA). Patients with multifocal ICCA were selected from the SEER (Surveillance, Epidemiology, and End Results) database between 2010 and...

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Autores principales:	Linlin Yin, Si Zhao, Hanlong Zhu, Guozhong Ji, Xiuhua Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07baa67ad480478898c405cbdc1a0546
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spelling	oai:doaj.org-article:07baa67ad480478898c405cbdc1a05462021-12-02T17:34:49ZPrimary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study10.1038/s41598-021-91823-x2045-2322https://doaj.org/article/07baa67ad480478898c405cbdc1a05462021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91823-xhttps://doaj.org/toc/2045-2322Abstract The purpose of our study was to evaluate the effect of surgery on the survival and prognosis of patients with multifocal intrahepatic cholangiocarcinoma (ICCA). Patients with multifocal ICCA were selected from the SEER (Surveillance, Epidemiology, and End Results) database between 2010 and 2016. Kaplan–Meier analyses and log-rank tests were used to evaluate the difference in survival between the surgery group and the non-surgery group. We applied the Cox proportional hazards regression model to identify prognostic factors of overall survival (OS) and cancer-specific survival (CSS). In total, 580 patients were enrolled in our study, including 151 patients who underwent surgery and 429 patients who did not. The median survival time of surgical patients was longer than non-surgical patients (OS: 25 months vs. 8 months, p < 0.001; CSS: 40 months vs. 25 months, p < 0.001). Similarly, the 5-year survival rate in the surgery group was significantly higher than those in the non-surgery group (5-year OS rate: 12.91% vs. 0%; p < 0.001; 5-year CSS rate:26.91% vs. 0%; p < 0.001). Multivariate Cox analysis showed that the OS (HR:0.299, 95% CI: 0.229–0.390, p < 0.001) and CSS (HR:0.305, 95% CI:0.222–0.419, p < 0.001) of patients undergoing surgical resection were significantly improved. Meanwhile, after propensity score matching (PSM) of the original data, we come to the same conclusion.Linlin YinSi ZhaoHanlong ZhuGuozhong JiXiuhua ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linlin Yin Si Zhao Hanlong Zhu Guozhong Ji Xiuhua Zhang Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
description	Abstract The purpose of our study was to evaluate the effect of surgery on the survival and prognosis of patients with multifocal intrahepatic cholangiocarcinoma (ICCA). Patients with multifocal ICCA were selected from the SEER (Surveillance, Epidemiology, and End Results) database between 2010 and 2016. Kaplan–Meier analyses and log-rank tests were used to evaluate the difference in survival between the surgery group and the non-surgery group. We applied the Cox proportional hazards regression model to identify prognostic factors of overall survival (OS) and cancer-specific survival (CSS). In total, 580 patients were enrolled in our study, including 151 patients who underwent surgery and 429 patients who did not. The median survival time of surgical patients was longer than non-surgical patients (OS: 25 months vs. 8 months, p < 0.001; CSS: 40 months vs. 25 months, p < 0.001). Similarly, the 5-year survival rate in the surgery group was significantly higher than those in the non-surgery group (5-year OS rate: 12.91% vs. 0%; p < 0.001; 5-year CSS rate:26.91% vs. 0%; p < 0.001). Multivariate Cox analysis showed that the OS (HR:0.299, 95% CI: 0.229–0.390, p < 0.001) and CSS (HR:0.305, 95% CI:0.222–0.419, p < 0.001) of patients undergoing surgical resection were significantly improved. Meanwhile, after propensity score matching (PSM) of the original data, we come to the same conclusion.
format	article
author	Linlin Yin Si Zhao Hanlong Zhu Guozhong Ji Xiuhua Zhang
author_facet	Linlin Yin Si Zhao Hanlong Zhu Guozhong Ji Xiuhua Zhang
author_sort	Linlin Yin
title	Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
title_short	Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
title_full	Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
title_fullStr	Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
title_full_unstemmed	Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
title_sort	primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07baa67ad480478898c405cbdc1a0546
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Primary tumor resection improves survival in patients with multifocal intrahepatic cholangiocarcinoma based on a population study

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