Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

It has been proposed that resistance to targeted therapies in non-small cell lung carcinoma (NSCLC) is due to a nonhomogeneous cell population. Here the authors analyse preclinical NSCLC models using single-cell RNA-seq and identify drug tolerant cell states and subpopulations, as well as associated...

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Autores principales:	Alexandre F. Aissa, Abul B. M. M. K. Islam, Majd M. Ariss, Cammille C. Go, Alexandra E. Rader, Ryan D. Conrardy, Alexa M. Gajda, Carlota Rubio-Perez, Klara Valyi-Nagy, Mary Pasquinelli, Lawrence E. Feldman, Stefan J. Green, Nuria Lopez-Bigas, Maxim V. Frolov, Elizaveta V. Benevolenskaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c903
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spelling	oai:doaj.org-article:07bdc3f7e13d4e018edb5f1887d9c9032021-12-02T13:16:18ZSingle-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer10.1038/s41467-021-21884-z2041-1723https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c9032021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21884-zhttps://doaj.org/toc/2041-1723It has been proposed that resistance to targeted therapies in non-small cell lung carcinoma (NSCLC) is due to a nonhomogeneous cell population. Here the authors analyse preclinical NSCLC models using single-cell RNA-seq and identify drug tolerant cell states and subpopulations, as well as associated genes.Alexandre F. AissaAbul B. M. M. K. IslamMajd M. ArissCammille C. GoAlexandra E. RaderRyan D. ConrardyAlexa M. GajdaCarlota Rubio-PerezKlara Valyi-NagyMary PasquinelliLawrence E. FeldmanStefan J. GreenNuria Lopez-BigasMaxim V. FrolovElizaveta V. BenevolenskayaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandre F. Aissa Abul B. M. M. K. Islam Majd M. Ariss Cammille C. Go Alexandra E. Rader Ryan D. Conrardy Alexa M. Gajda Carlota Rubio-Perez Klara Valyi-Nagy Mary Pasquinelli Lawrence E. Feldman Stefan J. Green Nuria Lopez-Bigas Maxim V. Frolov Elizaveta V. Benevolenskaya Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
description	It has been proposed that resistance to targeted therapies in non-small cell lung carcinoma (NSCLC) is due to a nonhomogeneous cell population. Here the authors analyse preclinical NSCLC models using single-cell RNA-seq and identify drug tolerant cell states and subpopulations, as well as associated genes.
format	article
author	Alexandre F. Aissa Abul B. M. M. K. Islam Majd M. Ariss Cammille C. Go Alexandra E. Rader Ryan D. Conrardy Alexa M. Gajda Carlota Rubio-Perez Klara Valyi-Nagy Mary Pasquinelli Lawrence E. Feldman Stefan J. Green Nuria Lopez-Bigas Maxim V. Frolov Elizaveta V. Benevolenskaya
author_facet	Alexandre F. Aissa Abul B. M. M. K. Islam Majd M. Ariss Cammille C. Go Alexandra E. Rader Ryan D. Conrardy Alexa M. Gajda Carlota Rubio-Perez Klara Valyi-Nagy Mary Pasquinelli Lawrence E. Feldman Stefan J. Green Nuria Lopez-Bigas Maxim V. Frolov Elizaveta V. Benevolenskaya
author_sort	Alexandre F. Aissa
title	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
title_short	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
title_full	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
title_fullStr	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
title_full_unstemmed	Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
title_sort	single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c903
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Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

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