Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

It has been proposed that resistance to targeted therapies in non-small cell lung carcinoma (NSCLC) is due to a nonhomogeneous cell population. Here the authors analyse preclinical NSCLC models using single-cell RNA-seq and identify drug tolerant cell states and subpopulations, as well as associated...

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Autores principales: Alexandre F. Aissa, Abul B. M. M. K. Islam, Majd M. Ariss, Cammille C. Go, Alexandra E. Rader, Ryan D. Conrardy, Alexa M. Gajda, Carlota Rubio-Perez, Klara Valyi-Nagy, Mary Pasquinelli, Lawrence E. Feldman, Stefan J. Green, Nuria Lopez-Bigas, Maxim V. Frolov, Elizaveta V. Benevolenskaya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c903
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