Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?

The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis. In sepsis, damage of the eGC triggers the development of vascular hyperpermeability with consecutive edema formation...

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Autores principales:	Carolin Christina Drost, Alexandros Rovas, Philipp Kümpers
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Glycocalyx Sepsis Heparanase Perfused boundary region Glycosaminoglycan Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/07bde36f1063472bbd001973528e944b
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spelling	oai:doaj.org-article:07bde36f1063472bbd001973528e944b2021-11-26T04:38:48ZProtection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?2590-028510.1016/j.mbplus.2021.100091https://doaj.org/article/07bde36f1063472bbd001973528e944b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590028521000351https://doaj.org/toc/2590-0285The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis. In sepsis, damage of the eGC triggers the development of vascular hyperpermeability with consecutive edema formation and organ failure. While there is evidence that protection or rebuilding of the eGC might counteract sepsis-induced vascular leakage and improve outcome, approved therapeutics are not yet available. This narrative review aims to outline possible therapeutic strategies to ameliorate organ dysfunction caused by eGC impairment.Carolin Christina DrostAlexandros RovasPhilipp KümpersElsevierarticleGlycocalyxSepsisHeparanasePerfused boundary regionGlycosaminoglycanBiology (General)QH301-705.5ENMatrix Biology Plus, Vol 12, Iss , Pp 100091- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glycocalyx Sepsis Heparanase Perfused boundary region Glycosaminoglycan Biology (General) QH301-705.5
spellingShingle	Glycocalyx Sepsis Heparanase Perfused boundary region Glycosaminoglycan Biology (General) QH301-705.5 Carolin Christina Drost Alexandros Rovas Philipp Kümpers Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
description	The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis. In sepsis, damage of the eGC triggers the development of vascular hyperpermeability with consecutive edema formation and organ failure. While there is evidence that protection or rebuilding of the eGC might counteract sepsis-induced vascular leakage and improve outcome, approved therapeutics are not yet available. This narrative review aims to outline possible therapeutic strategies to ameliorate organ dysfunction caused by eGC impairment.
format	article
author	Carolin Christina Drost Alexandros Rovas Philipp Kümpers
author_facet	Carolin Christina Drost Alexandros Rovas Philipp Kümpers
author_sort	Carolin Christina Drost
title	Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
title_short	Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
title_full	Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
title_fullStr	Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
title_full_unstemmed	Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?
title_sort	protection and rebuilding of the endothelial glycocalyx in sepsis – science or fiction?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/07bde36f1063472bbd001973528e944b
work_keys_str_mv	AT carolinchristinadrost protectionandrebuildingoftheendothelialglycocalyxinsepsisscienceorfiction AT alexandrosrovas protectionandrebuildingoftheendothelialglycocalyxinsepsisscienceorfiction AT philippkumpers protectionandrebuildingoftheendothelialglycocalyxinsepsisscienceorfiction
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Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction?

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