Robustness and lethality in multilayer biological molecular networks

Robustness is a prominent feature of most biological systems, but most of the current efforts have been focused on studying homogeneous molecular networks. Here the authors propose a comprehensive framework for understanding how the interactions between genes, proteins, and metabolites contribute to...

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Autores principales: Xueming Liu, Enrico Maiorino, Arda Halu, Kimberly Glass, Rashmi B. Prasad, Joseph Loscalzo, Jianxi Gao, Amitabh Sharma
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/07c2f37c5d30453babf20426c0d4165d
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spelling oai:doaj.org-article:07c2f37c5d30453babf20426c0d4165d2021-12-02T16:49:28ZRobustness and lethality in multilayer biological molecular networks10.1038/s41467-020-19841-32041-1723https://doaj.org/article/07c2f37c5d30453babf20426c0d4165d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19841-3https://doaj.org/toc/2041-1723Robustness is a prominent feature of most biological systems, but most of the current efforts have been focused on studying homogeneous molecular networks. Here the authors propose a comprehensive framework for understanding how the interactions between genes, proteins, and metabolites contribute to the determinants of robustness.Xueming LiuEnrico MaiorinoArda HaluKimberly GlassRashmi B. PrasadJoseph LoscalzoJianxi GaoAmitabh SharmaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xueming Liu
Enrico Maiorino
Arda Halu
Kimberly Glass
Rashmi B. Prasad
Joseph Loscalzo
Jianxi Gao
Amitabh Sharma
Robustness and lethality in multilayer biological molecular networks
description Robustness is a prominent feature of most biological systems, but most of the current efforts have been focused on studying homogeneous molecular networks. Here the authors propose a comprehensive framework for understanding how the interactions between genes, proteins, and metabolites contribute to the determinants of robustness.
format article
author Xueming Liu
Enrico Maiorino
Arda Halu
Kimberly Glass
Rashmi B. Prasad
Joseph Loscalzo
Jianxi Gao
Amitabh Sharma
author_facet Xueming Liu
Enrico Maiorino
Arda Halu
Kimberly Glass
Rashmi B. Prasad
Joseph Loscalzo
Jianxi Gao
Amitabh Sharma
author_sort Xueming Liu
title Robustness and lethality in multilayer biological molecular networks
title_short Robustness and lethality in multilayer biological molecular networks
title_full Robustness and lethality in multilayer biological molecular networks
title_fullStr Robustness and lethality in multilayer biological molecular networks
title_full_unstemmed Robustness and lethality in multilayer biological molecular networks
title_sort robustness and lethality in multilayer biological molecular networks
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/07c2f37c5d30453babf20426c0d4165d
work_keys_str_mv AT xuemingliu robustnessandlethalityinmultilayerbiologicalmolecularnetworks
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AT kimberlyglass robustnessandlethalityinmultilayerbiologicalmolecularnetworks
AT rashmibprasad robustnessandlethalityinmultilayerbiologicalmolecularnetworks
AT josephloscalzo robustnessandlethalityinmultilayerbiologicalmolecularnetworks
AT jianxigao robustnessandlethalityinmultilayerbiologicalmolecularnetworks
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