LSD1: Expanding Functions in Stem Cells and Differentiation

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the bala...

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Autores principales:	Carlos Martinez-Gamero, Sandhya Malla, Francesca Aguilo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	LSD1 KDM1A lysine-specific demethylase epigenetics histone methylation non-histone substrate Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/07c4e612f26e48c68129f45e46c3a2c7
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id	oai:doaj.org-article:07c4e612f26e48c68129f45e46c3a2c7
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spelling	oai:doaj.org-article:07c4e612f26e48c68129f45e46c3a2c72021-11-25T17:13:18ZLSD1: Expanding Functions in Stem Cells and Differentiation10.3390/cells101132522073-4409https://doaj.org/article/07c4e612f26e48c68129f45e46c3a2c72021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3252https://doaj.org/toc/2073-4409Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency.Carlos Martinez-GameroSandhya MallaFrancesca AguiloMDPI AGarticleLSD1KDM1Alysine-specific demethylaseepigeneticshistone methylationnon-histone substrateBiology (General)QH301-705.5ENCells, Vol 10, Iss 3252, p 3252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	LSD1 KDM1A lysine-specific demethylase epigenetics histone methylation non-histone substrate Biology (General) QH301-705.5
spellingShingle	LSD1 KDM1A lysine-specific demethylase epigenetics histone methylation non-histone substrate Biology (General) QH301-705.5 Carlos Martinez-Gamero Sandhya Malla Francesca Aguilo LSD1: Expanding Functions in Stem Cells and Differentiation
description	Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), the first identified histone lysine demethylase, demethylates H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. Moreover, it has also been shown to demethylate non-histone substrates playing a central role in the regulation of numerous cellular processes. In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency.
format	article
author	Carlos Martinez-Gamero Sandhya Malla Francesca Aguilo
author_facet	Carlos Martinez-Gamero Sandhya Malla Francesca Aguilo
author_sort	Carlos Martinez-Gamero
title	LSD1: Expanding Functions in Stem Cells and Differentiation
title_short	LSD1: Expanding Functions in Stem Cells and Differentiation
title_full	LSD1: Expanding Functions in Stem Cells and Differentiation
title_fullStr	LSD1: Expanding Functions in Stem Cells and Differentiation
title_full_unstemmed	LSD1: Expanding Functions in Stem Cells and Differentiation
title_sort	lsd1: expanding functions in stem cells and differentiation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/07c4e612f26e48c68129f45e46c3a2c7
work_keys_str_mv	AT carlosmartinezgamero lsd1expandingfunctionsinstemcellsanddifferentiation AT sandhyamalla lsd1expandingfunctionsinstemcellsanddifferentiation AT francescaaguilo lsd1expandingfunctionsinstemcellsanddifferentiation
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LSD1: Expanding Functions in Stem Cells and Differentiation

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