Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Xiaoping Luo,1,2 Linghong Guo,1 Xi-Jian Dai,3 Qinglai Wang,2 Wenzhong Zhu,2 Xinjun Miao,2 Honghan Gong1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Radiology, Wenzhou Chinese Medicine Hospit...

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Autores principales:	Luo X, Guo LH, Dai XJ, Wang Q, Zhu W, Miao X, Gong H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Alcohol dependence Degree centrality Functional magnetic resonance imaging Functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/07c4f3e513a04d60a20b73703b9adc15
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spelling	oai:doaj.org-article:07c4f3e513a04d60a20b73703b9adc152021-12-02T02:57:50ZAbnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis1178-2021https://doaj.org/article/07c4f3e513a04d60a20b73703b9adc152017-07-01T00:00:00Zhttps://www.dovepress.com/abnormal-intrinsic-functional-hubs-in-alcohol-dependence-evidence-from-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaoping Luo,1,2 Linghong Guo,1 Xi-Jian Dai,3 Qinglai Wang,2 Wenzhong Zhu,2 Xinjun Miao,2 Honghan Gong1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Radiology, Wenzhou Chinese Medicine Hospital, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People’s Republic of China Objective: To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features.Materials and methods: Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.Results: Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R2=0.296, P=0.006).Conclusion: The specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence. Keywords: alcohol addiction, substance dependence, degree centrality, functional magnetic resonance imaging, functional connectivity driving behaviorLuo XGuo LHDai XJWang QZhu WMiao XGong HDove Medical PressarticleAlcohol dependenceDegree centralityFunctional magnetic resonance imagingFunctional connectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2011-2020 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alcohol dependence Degree centrality Functional magnetic resonance imaging Functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Alcohol dependence Degree centrality Functional magnetic resonance imaging Functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Luo X Guo LH Dai XJ Wang Q Zhu W Miao X Gong H Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
description	Xiaoping Luo,1,2 Linghong Guo,1 Xi-Jian Dai,3 Qinglai Wang,2 Wenzhong Zhu,2 Xinjun Miao,2 Honghan Gong1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Radiology, Wenzhou Chinese Medicine Hospital, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People’s Republic of China Objective: To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features.Materials and methods: Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.Results: Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R2=0.296, P=0.006).Conclusion: The specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence. Keywords: alcohol addiction, substance dependence, degree centrality, functional magnetic resonance imaging, functional connectivity driving behavior
format	article
author	Luo X Guo LH Dai XJ Wang Q Zhu W Miao X Gong H
author_facet	Luo X Guo LH Dai XJ Wang Q Zhu W Miao X Gong H
author_sort	Luo X
title	Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
title_short	Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
title_full	Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
title_fullStr	Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
title_full_unstemmed	Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
title_sort	abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/07c4f3e513a04d60a20b73703b9adc15
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Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

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