Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondar...

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Autores principales:	Hee Ryung Kim, Jun Xu, Shoji Maeda, Nguyen Minh Duc, Donghoon Ahn, Yang Du, Ka Young Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07c8ff45757c4596b553213efaff5436
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id	oai:doaj.org-article:07c8ff45757c4596b553213efaff5436
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spelling	oai:doaj.org-article:07c8ff45757c4596b553213efaff54362021-12-02T17:14:28ZStructural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family10.1038/s41467-020-16975-22041-1723https://doaj.org/article/07c8ff45757c4596b553213efaff54362020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16975-2https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondary Gi/o coupling.Hee Ryung KimJun XuShoji MaedaNguyen Minh DucDonghoon AhnYang DuKa Young ChungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hee Ryung Kim Jun Xu Shoji Maeda Nguyen Minh Duc Donghoon Ahn Yang Du Ka Young Chung Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
description	G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondary Gi/o coupling.
format	article
author	Hee Ryung Kim Jun Xu Shoji Maeda Nguyen Minh Duc Donghoon Ahn Yang Du Ka Young Chung
author_facet	Hee Ryung Kim Jun Xu Shoji Maeda Nguyen Minh Duc Donghoon Ahn Yang Du Ka Young Chung
author_sort	Hee Ryung Kim
title	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
title_short	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
title_full	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
title_fullStr	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
title_full_unstemmed	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family
title_sort	structural mechanism underlying primary and secondary coupling between gpcrs and the gi/o family
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/07c8ff45757c4596b553213efaff5436
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Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

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